Observational studyMedical molecular morphology2020
Variants in taste genes on caries risk and caries activity status.
Observational study in Medical molecular morphology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04066101 (Variants in Taste Genes on Caries Risk and Caries Activity Status), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Variants in Taste Genes on Caries Risk and Caries Activity Status
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.Clinical oral investigations · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to evaluate the role of taste-related gene polymorphisms (CA6, TAS1R1, TAS1R3, TLR2, and TLR4) on dental caries and caries activity in adults. Individuals aged 25-44 years included in the study were assigned to two groups according to the decayed-missing-filled teeth index (DMFT) as the high caries risk (DMFT ≥ 14, n = 100) and the low caries risk (DMFT ≤ 5, n = 100). TaqMan allelic discrimination assays were used for genotyping the gene variants after isolating the DNA from the buccal smears. According to the American dental association caries classification system (ADA CCS), all teeth were scored as initial, moderate or advanced caries. The variant of the gustin (CA6) in saliva was found to be associated with a high caries risk (CA6 rs17032907, P < .001). There was also a statistically significant difference in the dominant model of the same variant (CC vs. TT: P < .001, OR = 5.05, 95% CI: 2.38-10.71). The presence of genotype CC and allele C was less frequent in the advanced caries lesion group (P < .001). This study shows that the CA6 rs17032907 gene variant may be a risk factor for dental caries affecting caries activity. Clinical Trials ID: NCT04066101.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.