ArticleUrolithiasis2020
Oral chemolysis is an effective, non-invasive therapy for urinary stones suspected of uric acid content.
Article in Urolithiasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Machine learning integrating CT radiomics and clinical variables for preoperative prediction of renal uric acid stones: a model development and validation study.Translational andrology and urology · 2026Article
- Staghorn uric acid stones: oral chemolysis outcomes and development of a nomogram for treatment success.Urolithiasis · 2026Article
- Kidney stones and autosomal dominant polycystic kidney disease: a state-of-the-art review.Renal failure · 2025Review
- Kidney stone disease: risk factors, pathophysiology and management.Nature reviews. Nephrology · 2025Review
- Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots.Advanced healthcare materials · 2025Article
- Article
- Construction and validation of a urinary stone composition prediction model based on machine learning.Urolithiasis · 2025Article
- A Fresh Look at Oral Chemolysis for Non-Symptomatic Kidney Stones-Comparative Research of Potassium Citrate and Allopurinol Combination-Is Treatment Possible Without Stone Analysis?Journal of clinical medicine · 2025Article
- The influence and relationship of dysbiosis in the urinary microbiota on patients with urolithiasis.Urolithiasis · 2025Article
- Medical treatment of uric acid kidney stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- A nomogram to predict "pure" vs. "mixed" uric acid urinary stones.World journal of urology · 2024Article
- Advancements in stone classification: unveiling the beauty of urolithiasis.World journal of urology · 2024Review
- Mixed stones: urinary stone composition, frequency and distribution by gender and age.Urolithiasis · 2024Article
- Development and external validation of a machine learning-based model to classify uric acid stones in patients with kidney stones of Hounsfield units < 800.Urolithiasis · 2023Article
- A combined model based on CT radiomics and clinical variables to predict uric acid calculi which have a good accuracy.Urolithiasis · 2023Article
- Is medical dissolution treatment for uric acid stones more cost-effective than surgical treatment? A novel, solo practice, retrospective cost-analysis of medical vs. surgical therapy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023Article
- Effect of theobromine on dissolution of uric acid kidney stones.World journal of urology · 2022Article
- Article
- Outcomes and rates of dissolution therapy for uric acid stones.Journal of nephrology · 2022Article
- Towards automatic recognition of pure and mixed stones using intra-operative endoscopic digital images.BJU international · 2022Article
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6 authors.
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Abstract
Despite the possible benefit from avoiding stone surgery with all its possible complications, oral chemolysis is rarely performed in patients with urinary stones suspected of uric acid content. Among the reasons for its limited use is the sparse and low-quality data on its efficacy and the lack of reliable factors predicting its outcome. We thus performed a retrospective single-center cohort study of 216 patients (median patient age 63 years) with 272 renal (48%) and/or ureteral (52%) stones treated with oral chemolysis from 01/2010 to 12/2019. Patients with low urine pH (< 6), low stone density upon non-contrast enhanced computed tomography (NCCT), radiolucent urinary stones on plain radiography, and/or a history of uric acid urolithiasis were included. Potassium citrate and/or sodium/magnesium bicarbonate were used for alkalization (target urine pH 6.5-7.2). Median stone size was 9 mm, median stone density 430 Hounsfield Units. Patients with ureteral stones < 6 mm were excluded since stones this small are very likely to pass spontaneously. The stone-free status of each patient was evaluated after 3 months using NCCT. Oral chemolysis was effective with a complete and partial response rate of stones at 3 months of 61% and 14%, respectively; 25% of stones could not be dissolved. Lower stone density (OR = 0.997 [CI 0.994-0.999]; p = 0.008) and smaller stone size (OR = 0.959 [CI 0.924-0.995]; p = 0.025) significantly increased the success rate of oral chemolysis in multivariate logistic regression analysis. More precise stone diagnostics to exclude non-uric-acid stones could further improve outcome.
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