Evidence map›Paper›PMID 32770207›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Sex Hormones and Incident Heart Failure in Men and Postmenopausal Women: The Atherosclerosis Risk in Communities Study.

Di Zhao, Eliseo Guallar, Christie M Ballantyne, Wendy S Post, Pamela Ouyang, Dhananjay Vaidya, Xiaoming Jia, Wendy Ying, Vinita Subramanya, Chiadi E Ndumele and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
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  6. Article
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  11. Association of testosterone with myocardial infarction and severity of coronary artery disease among male patients.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Editorial: Sex differences and cardiovascular therapeutics.Frontiers in cardiovascular medicine · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Di ZhaoDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Eliseo GuallarDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine; The Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Texas.
Wendy S PostDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Pamela OuyangDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dhananjay VaidyaDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Xiaoming JiaBaylor College of Medicine, Houston, Texas.
Wendy YingDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Vinita SubramanyaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Chiadi E NdumeleDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Ron C HoogeveenSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine; The Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Texas.
Erin D MichosDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University · USHouston Methodist · USBaylor College of Medicine · USEmory University · US

Funding

NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005I
6 · The paper itself

Abstract

contextSex differences exist in heart failure (HF) phenotypes, but there is limited research on the role of sex hormones in HF and its subtypes.

objectiveTo examine the associations of total testosterone, dehydroepiandrosterone sulfate (DHEA-S), and sex hormone-binding globulin (SHBG) with incident HF, HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF).

designAtherosclerosis Risk in Communities (ARIC) study (prospective cohort study). Median follow-up is 19.2 years.

settingGeneral community.

participants4107 men and 4839 postmenopausal women, with mean age of 63.2 (standard deviation [SD] 5.7) and 62.8 (5.5) years, respectively. EXPOSURE: Plasma sex hormone levels were measured at visit 4 (1996-1998).

main outcome measuresIncident HF events were identified through hospital discharge codes and death certificates.

resultsThe Hazard Ratios for HF associated with 1 SD decrease in log-transformed total testosterone, DHEA-S, and SHBG were 1.10 (95% confidence interval 1.03, 1.17), 1.07 (1.00, 1.15), and 1.04 (0.96, 1.11) in men, and 1.05 (0.99, 1.13), 1.17 (1.09, 1.24), and 0.93 (0.85, 1.01) in women, respectively. The associations between sex hormones with subtypes of HF had similar patterns but were attenuated and became statistically insignificant.

conclusionIn this prospective cohort, lower levels of endogenous testosterone and DHEA-S in men and DHEA-S in postmenopausal women were associated with the development of HF. Similar directions of association in both sexes and both HF subtypes suggest that sex hormones play a role in the development of HF through common pathways regardless of sex.

Indexed as

AgedAtherosclerosisDehydroepiandrosterone SulfateFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedPostmenopauseProspective StudiesSex FactorsSex Hormone-Binding GlobulinStroke VolumeTestosteroneDehydroepiandrosterone SulfateSex Hormone-Binding GlobulinTestosteroneDHEA-Sheart failureHFpEFHFrEFsex hormoneSHBGtestosterone

Identifiers

PMID32770207
PMCPMC7455306
OpenAlexW3048097152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.