ArticleNature medicine2020
A combined risk score enhances prediction of type 1 diabetes among susceptible children.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes.Hormone research in paediatrics · 2024Guideline
- Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study.Diabetologia · 2026Observational
- Improved prediction of symptomatic type 1 diabetes using a luciferase-based assay to measure (pro)insulin autoantibodies.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- Newborn screening for type 1 diabetes using genome-based risk scores in the Early Check program.American journal of human genetics · 2026Article
- Development of a Patient-Level Multi-objective Optimisation Model for Screening Strategies for Childhood Type 1 Diabetes.PharmacoEconomics · 2026Article
- Clinical, immunogenetic and metabolic characteristics of autoantibody-negative and autoantibody-positive type 1 diabetes.Diabetologia · 2026Article
- Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention.Diabetes care · 2026Article
- Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2026Article
- Article
- Risk estimation and dynamic prediction using discrete-time joint models for longitudinal and multistate data with interval and state censoring.Biostatistics (Oxford, England) · 2026Article
- Article
- Optimizing Type 1 Diabetes Screening in People With Family History: A German Perspective.Journal of diabetes science and technology · 2025Review
- Specification curve analysis of the TEDDY study reveals large variation in microbiome-based T1D predictive performance.Nature communications · 2025Article
- Towards IBD Prediction and Prevention: The Contribution of Genetics and Genomics.Inflammatory bowel diseases · 2025Review
- Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes.Molecular metabolism · 2025Article
- Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Nature reviews. Endocrinology · 2025Review
- A microRNA-based dynamic risk score for type 1 diabetes.Nature medicine · 2025Article
- Health economic considerations of screening for early type 1 diabetes.Diabetes, obesity & metabolism · 2025Review
- Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter.Diabetologia · 2025Article
- The pathophysiology, presentation and classification of Type 1 diabetes.Diabetes, obesity & metabolism · 2025Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 20 institutions in 5 countries.
Lauric A FerratInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0002-3166-9685
Kendra VehikHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6243-6772
Seth A SharpInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Åke LernmarkDepartment of Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.ORCID http://orcid.org/0000-0003-1735-0499
Marian J RewersBarbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Jin-Xiong SheCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.
Jorma ToppariDepartment of Pediatrics, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0003-2228-334X
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jeffrey P KrischerHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Michael N WeedonInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Richard A Oram *Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
William A Hagopian *Pacific Northwest Research Institute, Seattle, WA, USA. wah@uw.edu.ORCID http://orcid.org/0000-0003-2979-0475
TEDDY Study Group
University of South Florida · USLund University · SEPacific Northwest Diabetes Research Institute · USTampere University · FIUniversity of Colorado Denver · USBaylor College of Medicine · USUniversity of Turku · FITUM Klinikum · DEAugusta University · USOulu University Hospital · FIUniversity of Florida · USFlorida State University · USUniversity of Virginia · USUniversity of Bristol · GBChildren's Hospital of Pittsburgh · USGerman Center for Diabetes Research · DEUniversity of Exeter · GBFinnish Institute for Health and Welfare · FIHelmholtz Zentrum München · DEUniversity of Bonn · DE
Funding
Data Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0MData Coordinating CenterU01DK063790 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2002 to 2006
$50.1MColorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MVector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MFollow-up on Subjects, Integrative Data Analysis and Measurement of Viral Antibodies in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK124166 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2020 to 2022
$31.1MNIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4MEstablish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9MThe Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0MData Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0MThe Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5MThe Environmental Triggers of Diabetes (TEDDY) in SwedenU01DK063861 · NIDDK · UNIVERSITY OF WASHINGTON · PI LERNMARK, AKE · 2003 to 2022
$13.4MTHE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3MBreakthrough T1D 3-SRA-2019-827-S-BDiabetes UK 16/0005529Diabetes UK 17/0005757NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001082NIDDK NIH HHS HHSN267200700014CNIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK063790NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063829NIDDK NIH HHS U01 DK063836NIDDK NIH HHS U01 DK063861NIDDK NIH HHS U01 DK063863NIDDK NIH HHS U01 DK063865NIDDK NIH HHS U01 DK124166NIDDK NIH HHS UC4 DK063821NIDDK NIH HHS UC4 DK063829NIDDK NIH HHS UC4 DK063836NIDDK NIH HHS UC4 DK063861NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK063865NIDDK NIH HHS UC4 DK095300NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483Wellcome Trust
Abstract
Type 1 diabetes (T1D)-an autoimmune disease that destroys the pancreatic islets, resulting in insulin deficiency-often begins early in life when islet autoantibody appearance signals high risk
Indexed as
Risk AssessmentAutoantibodiesAutoimmunityChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGenetic Predisposition to DiseaseHumansInfantInfant, NewbornInsulinIslets of LangerhansKetosisMaleNeonatal ScreeningAutoantibodiesInsulin
Identifiers
What OpenQuestion holds
Textmetadata
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.