ArticleGenes and immunity2020
Caenorhabditis elegans saposin-like spp-9 is involved in specific innate immune responses.
Article in Genes and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
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- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
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- Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity.Aging cell · 2022Article
- Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans.Cell & bioscience · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Animals counter specific environmental challenges with a combination of broad and tailored host responses. One protein family enlisted in the innate immune response includes the saposin-like antimicrobial proteins. We investigated the expression of a Caenorhabditis elegans saposin-like gene, spp-9, in response to different stresses. spp-9 expression was detected in the intestine and six amphid neurons, including AWB and AWC. spp-9 expression is increased in response to starvation stress. In addition, we discovered pathogen-specific regulation of spp-9 that was not clearly demarcated by Gram nature of the bacterial challenge. Multiple molecular innate immune response pathways, including DBL-1/TGF-β-like, insulin-like, and p38/MAPK, regulate expression of spp-9. Our results suggest spp-9 is involved in targeted responses to a variety of abiotic and bacterial challenges that are coordinated by multiple signaling pathways.
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