ArticleNature communications2020
A neural circuit encoding mating states tunes defensive behavior in Drosophila.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Review
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Article
- Serotonin Signaling Modulates Sexual Receptivity of Virgin Female Drosophila.Neuroscience bulletin · 2022Article
- Article
- Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates.International journal of molecular sciences · 2021Review
- Genetic Transsynaptic Techniques for Mapping Neural Circuits inFrontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social context can dampen or amplify the perception of touch, and touch in turn conveys nuanced social information. However, the neural mechanism behind social regulation of mechanosensation is largely elusive. Here we report that fruit flies exhibit a strong defensive response to mechanical stimuli to their wings. In contrast, virgin female flies being courted by a male show a compromised defensive response to the stimuli, but following mating the response is enhanced. This state-dependent switch is mediated by a functional reconfiguration of a neural circuit labelled with the Tmc-L gene in the ventral nerve cord. The circuit receives excitatory inputs from peripheral mechanoreceptors and coordinates the defensive response. While male cues suppress it via a doublesex (dsx) neuronal pathway, mating sensitizes it by stimulating a group of uterine neurons and consequently activating a leucokinin-dependent pathway. Such a modulation is crucial for the balance between defense against body contacts and sexual receptivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.