ReviewJournal of human genetics2021
Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint.
Review in Journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.JAMA psychiatry · 2021Pooled it
- Genetic underpinnings of YMRS and MADRS scores variations in a bipolar sample.European archives of psychiatry and clinical neuroscience · 2026Article
- Genetic risk of chronic pain conditions associated with risk of suicide death through an integrative analysis of EHR and genomics data.Translational psychiatry · 2026Article
- Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction.American heart journal plus : cardiology research and practice · 2026Article
- Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk.JAMA network open · 2026Article
- Genetic Liability for Internalizing-Externalizing Traits in Mexican Youth: Moderation by Adversity.medRxiv : the preprint server for health sciences · 2025Article
- New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.Biological psychiatry · 2025Review
- Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety.Discover mental health · 2025Article
- Moving toward precision and personalized treatment strategies in psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia.Genomic psychiatry : advancing science from genes to society · 2025Article
- Leveraging haplotype information in heritability estimation and polygenic prediction.Nature communications · 2025Article
- An externally validated resting-state brain connectivity signature of pain-related learning.Communications biology · 2024Article
- Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol.Frontiers in psychiatry · 2024Article
- Intron retention as an excellent marker for diagnosing depression and for discovering new potential pathways for drug intervention.Frontiers in psychiatry · 2024Article
- Pharmacogenomics and response to lithium in bipolar disorder.Pharmacogenomics · 2024Review
- Stakeholder Perception of the Implementation of Genetic Risk Testing for Twelve Multifactorial Diseases.Genes · 2023Article
- Ethical, legal, and social implications of genetic risk prediction for multifactorial disease: a narrative review identifying concerns about interpretation and use of polygenic scores.Journal of community genetics · 2023Article
- Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes.Biological psychiatry global open science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Genome-wide association studies (GWASs) have detected many susceptible variants for common diseases, including psychiatric disorders. However, because of the small effect size of each variant, clinical utility that aims for risk prediction and/or diagnostic assistance based on the individual "variants" is difficult to use. Therefore, to improve the statistical power, polygenic risk score (PRS) has been established and applied in the GWAS as a robust analytic tool. Although PRS has potential predictive ability, because of its current "insufficient" discriminative power at the individual level for clinical use, it remains limited solely in the research area, specifically in the psychiatric field. For a better understanding of the PRS, in this review, we (1) introduce the clinical features of psychiatric disorders, (2) summarize the recent GWAS/PRS findings in the psychiatric disorders, (3) evaluate the problems of PRS, and (4) propose its possible utility to apply PRS into the psychiatric clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.