Evidence map›Paper›PMID 32770032›Full record

ArticleScientific reports2020

Precise 3D modulation of electro-optical parameters during neurotransmitter uncaging experiments with neurons in vitro.

Marco Cozzolino, Virginia Bazzurro, Elena Gatta, Paolo Bianchini, Elena Angeli, Mauro Robello, Alberto Diaspro

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Involvement of GABAThe European journal of neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marco Cozzolino *DIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy.
Virginia Bazzurro *DIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy.
Elena GattaDIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy.
Paolo BianchiniNanoscopy, CHT Erzelli, Istituto Italiano di Tecnologia, Genoa, Italy.
Elena AngeliDIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy.
Mauro RobelloDIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy.
Alberto DiasproDIFILAB, Department of Physics, University of Genoa, via Dodecaneso 33, 16143, Genoa, Italy. diaspro@fisica.unige.it.
University of Genoa · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium-bipyridinetriphenylphosphine-GABA (RuBi-GABA) is a caged compound that allows studying the neuronal transmission in a specific region of a neuron. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is bound to a caged group that blocks the interaction of the neurotransmitter with its receptor site. Following linear-one-photon (1P)-and non-linear-multi-photon-absorption of light, the covalent bond of the caged molecule is broken, and GABA is released. Such a controlled release in time and space allows investigating the interaction with its receptor in four dimensions (X,Y,Z,t). Taking advantage of this strategy, we succeeded in addressing the modulation of GABA

Indexed as

AnimalsCells, CulturedCerebellumgamma-Aminobutyric AcidLightMicroscopy, ConfocalMolecular ImagingNeuronsNeurotransmitter AgentsPatch-Clamp TechniquesRats, Sprague-DawleyReceptors, GABA-ASynaptic Transmissiongamma-Aminobutyric AcidNeurotransmitter AgentsReceptors, GABA-A

Identifiers

PMID32770032
PMCPMC7414112
OpenAlexW3048124915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.