Evidence map›Paper›PMID 32769976›Full record

ArticleNature communications2020

Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase.

Chun-Liang Chen, Lake N Paul, James C Mermoud, Calvin Nicklaus Steussy, Cynthia V Stauffacher

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  4. Article
  5. Dual Deletion ofInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Biochemistry of Terpenes and Recent Advances in Plant Protection.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chun-Liang ChenDepartment of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0003-4625-4340
Lake N PaulBioAnalysis, LLC, 1135 Dunton Street, Unit 2, Philadelphia, PA, 19123, USA.
James C MermoudDepartment of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Calvin Nicklaus SteussyDepartment of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Cynthia V StauffacherDepartment of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA. cstauffa@purdue.edu.ORCID http://orcid.org/0000-0002-3081-6903
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NCI NIH HHS P30 CA023168NIH HHS S10 OD012289
6 · The paper itself

Abstract

Mevalonate diphosphate decarboxylases (MDDs) catalyze the ATP-dependent-Mg

Indexed as

Amino Acid SequenceBinding SitesBiocatalysisCarboxy-LyasesConserved SequenceCrystallography, X-RayEnterococcus faecalisLigandsMetalsModels, MolecularProtein Structure, SecondarySubstrate SpecificityCarboxy-LyasesLigandsMetalspyrophosphomevalonate decarboxylase

Identifiers

PMID32769976
PMCPMC7414129
OpenAlexW3047788036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.