SynthesisMedicine2020
Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis.
Synthesis in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Article
- The prognostic value of mean platelet volume levels in germinal matrix hemorrhage- intraventricular hemorrhage in preterm infants.Pakistan journal of medical sciences · 2025Article
- Diagnostic and prognostic utility of salivary and serum procalcitonin, interleukin-6, and interleukin-10 in pediatric pneumonia: a prospective case-control study.Frontiers in pediatrics · 2025Article
- Diagnostic Value of Mean Platelet Volume, Neutrophil-to-Lymphocyte Ratio, and Platelet to Lymphocyte Ratio for Late-Onset Neonatal Sepsis.International journal of preventive medicine · 2025Article
- A deep dive into burn-mediated ARDS severity assessment: a retrospective study on hematological markers.Scientific reports · 2024Article
- Salivary C-reactive protein and mean platelet volume as possible diagnostic markers for late-onset neonatal pneumonia.World journal of clinical pediatrics · 2024Article
- Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Insight Into Neonatal Sepsis: An Overview.Cureus · 2023Review
- Diagnostic performance of routine blood parameters in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome.Journal of clinical laboratory analysis · 2023Article
- Group BAntibiotics (Basel, Switzerland) · 2023Review
- Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies.Children (Basel, Switzerland) · 2022Review
- Article
- Platelet parameters as a diagnostic marker in early diagnosis of neonatal sepsis- Seeking newer answers for older problems.Journal of family medicine and primary care · 2022Article
- Diagnosis of neonatal sepsis: the past, present and future.Pediatric research · 2022Review
- Economic and Diagnostic Biomarker Tests of Neonatal Sepsis: A Prospective Study from a Tertiary Care Hospital in a Low-Income Country.BioMed research international · 2022Article
- Clinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p.Journal of inflammation research · 2021Article
- Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates.Journal of immunology research · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increasing number of studies in recent years have identified mean platelet volume (MPV) as a predictive marker for neonatal sepsis. However, most of these studies focused on single regions, and therefore, the findings remain inconclusive. We, in this study, aimed to evaluate the potential of MPV as a biological indicator of neonatal sepsis through a systematic review and meta-analysis.
methodsWe searched PubMed, the Cochrane Library, Embase, and WanFang database for articles on MPV and neonatal sepsis, published from January 1, 1990 to December 31, 2018. We included 11 studies on 932 neonates with sepsis in this meta-analysis.
resultsThe overall meta-analysis showed that MPV was significantly higher in patients with neonatal sepsis compared with healthy controls. Subgroup analysis revealed that the type of diagnostic criteria, analyzer, analyte, and controls used in the studies affected the difference in MPV between patients and healthy controls.
conclusionMPV was significantly higher in the neonatal sepsis group compared to the control group. Therefore, in clinical practice, MPV could be used as an indicator for the early diagnosis of neonatal sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.