Evidence map›Paper›PMID 32769172›Full record

ArticleScience immunology2020

Functional heterogeneity of alveolar macrophage population based on expression of CXCL2.

Shengjie Xu-Vanpala, M Elizabeth Deerhake, Joshua D Wheaton, Morgan E Parker, Praveen R Juvvadi, Nancie MacIver, Maria Ciofani, Mari L Shinohara

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. The lung tissue environment inbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Single-cell transcriptomics reveal alveolar macrophage-specific responses in single-hit ozone exposure model in mice.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  5. Article
  6. Article
  7. Splenic PD-L1Research (Washington, D.C.) · 2026
    Article
  8. Article
  9. Review
  10. Mgl2Nature communications · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. The frequency of CD38Nature communications · 2024
    Article
  15. Article
  16. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
    Review
  17. The roles of tissue resident macrophages in health and cancer.Experimental hematology & oncology · 2024
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shengjie Xu-VanpalaDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-2716-6230
M Elizabeth DeerhakeDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-4061-5766
Joshua D WheatonDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-2785-3463
Morgan E ParkerDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-2610-8530
Praveen R JuvvadiDepartment of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-5112-7824
Nancie MacIverDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-3676-9391
Maria CiofaniDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-6472-5260
Mari L ShinoharaDepartment of Immunology, Duke University School of Medicine, Durham, NC 27710, USA. mari.shinohara@duke.edu.
Duke University · USAmgen (United States) · USDuke Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Role of osteopontin in innate immunity during infections and inflammationR01AI088100 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2011 to 2021
$4.3M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
The role of AP-1 family transcription factor networks in regulating TH17 cell effector identityR01GM115474 · NIGMS · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2016 to 2024
$3.2M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Mechanism to evade host immunity by Mucorales fungiR21AI135999 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2018 to 2019
$434k
Regulation of innate inflammation by CD40 signaling and intracellular osteopontinR21AI103584 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2014 to 2015
$432k
Protective role of dectin-1 signaling in an animal model of Multiple SclerosisF30AI140497 · NIAID · DUKE UNIVERSITY · PI DEERHAKE, MARION ELIZABETH · 2018 to 2021
$169k
NIAID NIH HHS F30 AI140497NIAID NIH HHS R01 AI088100NIAID NIH HHS R01 AI160737NIAID NIH HHS R21 AI103584NIAID NIH HHS R21 AI135999NIAID NIH HHS T32 AI052077NIGMS NIH HHS R01 GM115474NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Alveolar macrophages (AMs) are the major lung-resident macrophages and have contradictory functions. AMs maintain tolerance and tissue homeostasis, but they also initiate strong inflammatory responses. However, such opposing roles within the AM population were not known to be simultaneously generated and coexist. Here, we uncovered heterogeneous AM subpopulations generated in response to two distinct pulmonary fungal infections,

Indexed as

Aspergillus fumigatusAnimalsAspergillosisBronchoalveolar Lavage FluidChemokine CXCL2CryptococcosisFemaleLungMacrophages, AlveolarMaleMice, TransgenicChemokine CXCL2Cxcl2 protein, mouse

Identifiers

PMID32769172
PMCPMC7717592
OpenAlexW3048034760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.