ArticleeNeuro
Interhemispheric Callosal Projections Sharpen Frequency Tuning and Enforce Response Fidelity in Primary Auditory Cortex.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease.bioRxiv : the preprint server for biology · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing.Nature communications · 2023Article
- Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The local and long-range input landscape of inhibitory neurons in mouse auditory cortex.The Journal of comparative neurology · 2023Article
- Selective Interruption of Auditory Interhemispheric Cross Talk Impairs Discrimination Learning of Frequency-Modulated Tone Direction But Not Gap Detection and Discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The functional characterization of callosal connections.Progress in neurobiology · 2022Review
- Reduction of corpus callosum activity during whisking leads to interhemispheric decorrelation.Nature communications · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sensory cortical areas receive glutamatergic callosal projections that link information processing between brain hemispheres. In primary auditory cortex (A1), ipsilateral principal cells from a particular tonotopic region project to neurons in matching frequency space of the contralateral cortex. However, the role of interhemispheric projections in shaping cortical responses to sound and frequency tuning in awake animals is unclear. Here, we use translaminar single-unit recordings and optogenetic approaches to probe how callosal inputs modulate spontaneous and tone-evoked activity in A1 of awake mice. Brief activation of callosal inputs drove either short-latency increases or decreases in firing of individual neurons. Across all cortical layers, the majority of responsive regular spiking (RS) cells received short-latency inhibition, whereas fast spiking (FS) cells were almost exclusively excited. Consistent with the callosal-evoked increases in FS cell activity
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.