Evidence map›Paper›PMID 32768924›Full record

ReviewCurrent opinion in cell biology2020

Mechanical regulation of cell size, fate, and behavior during asymmetric cell division.

Melissa K Delgado, Clemens Cabernard

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Altering cell size asymmetry inbioRxiv : the preprint server for biology · 2025
    Article
  5. Asymmetry of centrosomes inMolecular biology of the cell · 2025
    Article
  6. Article
  7. Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023
    Review
  8. Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains.Journal of visualized experiments : JoVE · 2023
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melissa K DelgadoDepartment of Biology, University of Washington, Life Science Building, Seattle, WA 98195, USA.
Clemens CabernardDepartment of Biology, University of Washington, Life Science Building, Seattle, WA 98195, USA. Electronic address: ccabern@uw.edu.

Funding

Cellular and molecular mechanisms underlying the formation of sibling cell size asymmetryR01GM126029 · NIGMS · UNIVERSITY OF WASHINGTON · PI CLEMENS C. CABERNARD, CLEMENS C · 2018 to 2022
$1.6M
NIGMS NIH HHS R01 GM126029
6 · The paper itself

Abstract

Asymmetric cell division (ACD) is an evolutionary conserved mechanism used by prokaryotes and eukaryotes alike to generate cell diversity. ACD can be manifested in biased segregation of macromolecules or differential partitioning of cell organelles. Cells are also constantly subject to extrinsic or intrinsic mechanical forces, influencing cell behavior and fate. During ACD, cell intrinsic forces generated through the spatiotemporal regulation of the actomyosin cytoskeleton can influence sibling cell size. External mechanical stresses are further translated by transcriptional coactivators or mechanically gated ion channels. Here, we will discuss recent literature, exploring how mechanical cues influence various aspects of ACD and stem cell behavior, and how these mechanical cues contribute to cell fate decisions.

Indexed as

Asymmetric Cell DivisionCell LineageCell SizeAnimalsBiomechanical PhenomenaHumansMechanotransduction, CellularStem CellsAsymmetric cell divisionMechanobiologySibling cell size asymmetrySpindle positioningStem cells

Identifiers

PMID32768924
PMCPMC7736100

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.