ArticleNeurobiology of aging2020
Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.Journal of affective disorders · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status.Alzheimer's research & therapy · 2024Article
- Cardiorespiratory Fitness and Muscular Strength Do Not Predict Social Cognitive Capacity in Older Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.NeuroImage · 2023Article
- Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults.Neurobiology of aging · 2023Article
- Pulse pressure trajectories predict brain microstructure in community-dwelling older adults: Associations with executive function and modification by APOE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Midlife omega-3 fatty acid intake predicts later life white matter microstructure in an age- and APOE-dependent manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Elevated Pure Tone Thresholds Are Associated with Altered Microstructure in Cortical Areas Related to Auditory Processing and Attentional Allocation.Journal of Alzheimer's disease : JAD · 2023Article
- A pilot [Brain, behavior, & immunity - health · 2021Article
- Age and Sex Differences in the Associations of Pulse Pressure With White Matter and Subcortical Microstructure.Hypertension (Dallas, Tex. : 1979) · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Cytoarchitectural brain changes during normal aging remain poorly characterized, and it is unclear whether patterns of brain aging differ by sex. This study used restriction spectrum imaging to examine associations between age and brain microstructure in 147 community-dwelling participants (aged 56-99 years). Widespread associations with age in multiple diffusion compartments, including increased free water, decreased restricted and hindered diffusion, and reduced neurite complexity, were observed in the cortical gray matter, the white matter tracts, and the hippocampus. Age differences in cortical microstructure were largely independent of atrophy. Associations were mostly global, although foci of stronger effects emerged in the fornix, anterior thalamic radiation and commissural fibers, and the medial temporal, orbitofrontal, and occipital cortices. Age differences were stronger and more widespread for women than men, even after adjustment for education, hypertension, and body mass index. Restriction spectrum imaging may be a convenient, noninvasive tool for monitoring changes in diffusion properties that are thought to reflect reduced cellular fractions and neurite density or complexity, which occur with typical aging, and for detecting sex differences in patterns of brain aging.
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