ArticleAmerican journal of obstetrics and gynecology2021
Associations of gestational cardiovascular health with pregnancy outcomes: the Hyperglycemia and Adverse Pregnancy Outcome study.
Article in American journal of obstetrics and gynecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Associations of body composition and physical fitness with gestational diabetes and cardiovascular health in pregnancy: Results from the HealthyMoms trial.Nutrition & diabetes · 2021Trial
- Gestational cardiovascular health and adverse pregnancy outcomes: a prospective cohort study in China.Annals of medicine · 2026Article
- Racial Differences in Adverse Pregnancy Outcomes and Incident Hypertension: A Mediation Analysis.Journal of the American Heart Association · 2026Article
- Adverse Pregnancy Outcomes and Prevalent Cardiovascular Disease Among an Urban Cohort in Haiti.JACC. Advances · 2026Article
- Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay.JAMA network open · 2026Article
- Cardiovascular health in pregnancy according to Life's Essential 8 score.NPJ cardiovascular health · 2026Article
- Trimester-specific association of gestational Atherogenic Index of Plasma (AIP) with adverse pregnancy outcomes among women with and without GDM: a cohort study.BMC endocrine disorders · 2026Article
- Racial/ethnic disparities in stages of cardiovascular-kidney-metabolic syndrome among reproductive-aged women in the United States: NHANES 2011-2020.Pregnancy (Hoboken, N.J.) · 2026Article
- Identifying cardiovascular health profiles in early pregnancy: A "Life's Essential 8"-based approach to assessing risk of hypertensive disorders of pregnancy.Pregnancy hypertension · 2025Observational
- Article
- Trends and Racial and Ethnic Disparities in Maternal Cardiovascular Health in California.Journal of the American Heart Association · 2025Article
- Lower Prepregnancy Cardiovascular Health is Associated With Hypertensive Disorders of Pregnancy: The CARDIA Study.Hypertension (Dallas, Tex. : 1979) · 2025Observational
- Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes.Scientific reports · 2025Article
- Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women.Journal of the American College of Cardiology · 2025Observational
- Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy.American journal of preventive cardiology · 2025Article
- Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy.Circulation. Cardiovascular quality and outcomes · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Prospective transitions in hemoglobin A1c following gestational diabetes using multistate Markov models.American journal of epidemiology · 2025Article
- Long-Term Cardiovascular and Metabolic Health Outcomes of Gestational Diabetes Mellitus: A Systematic Review.Cureus · 2025Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe American Heart Association's formal characterization of cardiovascular health combines several metrics in a health-oriented, rather than disease-oriented, framework. Although cardiovascular health assessment during pregnancy has been recommended, its significance for pregnancy outcomes is unknown.
objectiveThe purpose of this study was to examine the association of gestational cardiovascular health-formally characterized by a combination of 5 metrics-with adverse maternal and newborn outcomes. STUDY
designWe analyzed data from the Hyperglycemia and Adverse Pregnancy Outcome study, including 2304 mother-newborn dyads from 6 countries. Maternal cardiovascular health was defined by the combination of the following 5 metrics measured at a mean of 28 (24-32) weeks' gestation: body mass index, blood pressure, lipids, glucose, and smoking. Levels of each metric were categorized using pregnancy guidelines, and the total cardiovascular health was scored (0-10 points, where 10 was the most favorable). Cord blood was collected at delivery, newborn anthropometrics were measured within 72 hours, and medical records were abstracted for obstetrical outcomes. Modified Poisson and multinomial logistic regression were used to test the associations of gestational cardiovascular health with pregnancy outcomes, adjusted for center and maternal and newborn characteristics.
resultsThe average age of women at study exam was 29.6 years old, and they delivered at a mean gestational age of 39.8 weeks. The mean total gestational cardiovascular health score was 8.6 (of 10); 36.3% had all ideal metrics and 7.5% had 2+ poor metrics. In fully adjusted models, each 1 point higher (more favorable) cardiovascular health score was associated with lower risks for preeclampsia (relative risk, 0.67 [95% confidence interval, 0.61-0.73]), unplanned primary cesarean delivery (0.88 [0.82-0.95]), newborn birthweight >90th percentile (0.81 [0.75-0.87]), sum of skinfolds >90th percentile (0.84 [0.77-0.92]), and insulin sensitivity <10th percentile (0.83 [0.77-0.90]). Cardiovascular health categories demonstrated graded associations with outcomes; for example, relative risks (95% confidence intervals) for preeclampsia were 3.13 (1.39-7.06), 5.34 (2.44-11.70), and 9.30 (3.95-21.86) for women with ≥1 intermediate, 1 poor, or ≥2 poor (vs all ideal) metrics, respectively.
conclusionMore favorable cardiovascular health at 24 to 32 weeks' gestation was associated with lower risks for several adverse pregnancy outcomes in a multinational cohort.
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