ArticleDevelopmental cell2020
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.
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Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed.
- The origins and progression of pyloric metaplasia following gastric mucosal injury.Physiological reviews · 2026Review
- Stress-Responsive Protein IFRD1 Protects Assembled Ribosomes via a Ribosome-Salvaging Mechanism.bioRxiv : the preprint server for biology · 2026Article
- Regulation of STK38 by autophagy governs YAP1 activity during paligenosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence that injury can causebioRxiv : the preprint server for biology · 2026Article
- Paligenosis: dual potential of mature cell plasticity in regeneration and tumorigenesis.MedScience · 2026Review
- Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience.Communications biology · 2026Article
- Endoscopic and histopathological phenotypes of early gastric neoplasia: toward an integrative host-response framework.Frontiers in oncology · 2026Review
- The Diverse Roles of Mitochondria in Regulating Cancer Metastasis.Current issues in molecular biology · 2025Review
- Blocking of CDC25B suppresses sarcoma progression via arresting cell cycle.Translational cancer research · 2025Article
- Autophagy in Tissue Repair and Regeneration.Cells · 2025Review
- H. Pylori-Facilitated TERT/Wnt/β-Catenin Triggers Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction.Cellular and molecular gastroenterology and hepatology · 2025Article
- Article
- Activation of fetal-like molecular programs during regeneration in the intestine and beyond.Cell stem cell · 2024Review
- Origins of cancer: ain't it just mature cells misbehaving?The EMBO journal · 2024Review
- IFRD1 promotes tumor cells "low-cost" survival under glutamine starvation via inhibiting histone H1.0 nucleophagy.Cell discovery · 2024Article
- Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Review
- A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasis.bioRxiv : the preprint server for biology · 2024Article
- Article
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Authors and funding
18 authors.
Zhi-Feng MiaoDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, First Hospital of China Medical University, Shenyang 110001, China.
Mark A LewisDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Charles J ChoDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mahliyah Adkins-ThreatsDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dongkook ParkDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey W BrownDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jing-Xu SunDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, First Hospital of China Medical University, Shenyang 110001, China.
Joseph R BurclaffDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Susan KennedyDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jianyun LuDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marcus MaharDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Ilja VietorDivision of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Lukas A HuberDivision of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Nicholas O DavidsonDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Valeria CavalliDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Deborah C RubinDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Zhen-Ning WangDepartment of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, First Hospital of China Medical University, Shenyang 110001, China. Electronic address: josieon826@sina.cn.
Jason C MillsDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: jmills@wustl.edu.
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MCLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3MREGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1MHEPATIC SYNTHESIS AND SECRETION OF APOLIPOPROTEIN (A)R01DK056260 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1999 to 2017
$5.9MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MMECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.R37HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 2000 to 2009
$5.1MMAXIMIZING STUDENT DIVERSITY IN THE BIOMEDICAL SCIENCES AT WASHINGTON UNIVERSITYR25GM103757 · NIGMS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 2013 to 2022
$4.5MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESISR01HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1986 to 2018
$3.8MNCI NIH HHS P30 CA091842NCI NIH HHS R01 CA239645NCI NIH HHS R01 CA246208NHLBI NIH HHS R01 HL038180NHLBI NIH HHS R37 HL038180NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK056260NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK106382NIDDK NIH HHS R01 DK110406NIDDK NIH HHS R01 DK112378NIDDK NIH HHS R56 DK110406NIDDK NIH HHS T32 DK007130NIDDK NIH HHS T32 DK077653NIGMS NIH HHS R25 GM103757NIGMS NIH HHS T32 GM007067NIH HHS P40 OD018537
Abstract
Differentiated cells can re-enter the cell cycle to repair tissue damage via a series of discrete morphological and molecular stages coordinated by the cellular energetics regulator mTORC1. We previously proposed the term "paligenosis" to describe this conserved cellular regeneration program. Here, we detail a molecular network regulating mTORC1 during paligenosis in both mouse pancreatic acinar and gastric chief cells. DDIT4 initially suppresses mTORC1 to induce autodegradation of differentiated cell components and damaged organelles. Later in paligenosis, IFRD1 suppresses p53 accumulation. Ifrd1
Indexed as
AnimalsCell CycleCell DifferentiationCell DivisionCell ProliferationCell TransdifferentiationLicensureMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 1acinar-ductal metaplasiaADMDrosophilaregenerationSchizosaccharomyces pombespasmolytic polypeptide-expressing metaplasiaSPEM
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.