ReviewVeterinary microbiology2020
Canine parvovirus vaccination and immunisation failures: Are we far from disease eradication?
Review in Veterinary microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 147 citations in OpenAlex.
- Canine parvovirus in Africa: Explaining persistent disease despite vaccination.Veterinary and animal science · 2026Review
- Vaccination Protocols in Canine Shelters in Northern Italy: A Survey of Current Practices.Animals : an open access journal from MDPI · 2026Article
- Article
- Survival patterns and prognostic factors associated with canine parvovirus infection in dogs presented at the KNUST Veterinary Teaching Hospital in Kumasi, Ghana.BMC veterinary research · 2026Article
- Histopathological Myocardial Changes and CPV-2 DNA Detection in Young Dogs: A Retrospective Study.Veterinary sciences · 2026Article
- Article
- Molecular Characterization of Representative CPV-2c Isolates and Establishment of VP2-Targeted Nanobody-Based Immunodetection Tools.Animals : an open access journal from MDPI · 2026Article
- Molecular Characteristics and Genetic Diversity of Canine Parvovirus in Shanghai, China, from 2016 to 2025.Microorganisms · 2026Article
- Canine parvovirus type 2 infection in vaccinated puppies: role of vaccination practices and viral antigenic variation.BMC veterinary research · 2026Article
- Development of canine parvovirus-neutralizing monoclonal antibodies from natural host and their germline gene usage.Applied microbiology and biotechnology · 2026Article
- Fermented Rapeseed Meal Improves Growth Performance, Antioxidant Capacity, and Intestinal Morphology of Broilers by Enhancing Nutritional Value and Reducing Antinutritional Factors.Animals : an open access journal from MDPI · 2026Article
- Leveraging single B cell antibody platforms to develop countermeasures against animal viral diseases: recent advances and future perspectives.Frontiers in veterinary science · 2026Review
- Acute hemorrhagic gastroenteritis caused by an "Asian" CPV-2c variant in a vaccinated dog from Slovakia (Central Europe): a case report.Frontiers in veterinary science · 2026Article
- Evaluating Protoparvovirus carnivoran1 Risk in Wild Carnivorans and Hunting Dogs in the Valencian Community, Eastern Spain.Transboundary and emerging diseases · 2026Article
- Deferoxamine Inhibits Canine Parvovirus by Suppressing Ferroptosis and Viral Replication.Veterinary sciences · 2025Article
- Isolation, Identification and Phylogenetic Analysis of Canine Parvovirus Type 2c in Two Regions of Iran.Veterinary medicine and science · 2025Article
- Monoclonal antibodies in veterinary antiviral immunotherapy: technologies, applications and challenges.Veterinary research communications · 2025Review
- Molecular Survey for Major Canine Enteric Viral Pathogens in Wild Carnivores, Northwestern Italy.Veterinary sciences · 2025Article
- Antibody Titer Testing in Dogs: Evaluation of Three Point-of-Care Tests for Canine Core Vaccine Antigens Compared to Virus Neutralization.Veterinary sciences · 2025Article
- Assessing Canine Parvovirus Vaccine Performance in Puppies with Maternally Derived Antibody: An Improved Study Design.Vaccines · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite extensive vaccination, canine parvovirus (CPV) remains a leading infectious cause of canine mortality, especially among juveniles. This review provides an update on CPV vaccine types and vaccination protocols. The design of CPV prevention strategies and vaccination programs with a goal of herd immunity has been hampered by deficiencies of studies that model companion animal viral infections and inform an understanding of the basic reproduction number. However, the most important issue in eradication of CPV disease is represented by immunisation failures including: i) the presence of interfering titres of maternally-derived antibodies; ii) the presence of non-responders; and iii) possible reversion to virulence. In contrast, the role of the CPV variants in immunisation failures is widely debated. Taking into account the reduced circulation of canine distemper virus and canine adenovirus type 1 in countries where extensive vaccination is carried out, more effort should be made to aim for CPV eradication, including antibody testing to determine the optimal time for vaccinations of pups and adults and homogeneous vaccine coverage of dog population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.