ArticleThe New phytologist2021
RPW8.1 enhances the ethylene-signaling pathway to feedback-attenuate its mediated cell death and disease resistance in Arabidopsis.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 37 citations in OpenAlex.
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- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- Examination of the Expression Profile of Resistance Genes in Yuanjiang Common Wild Rice (Genes · 2024Article
- Plant Immunity: At the Crossroads of Pathogen Perception and Defense Response.Plants (Basel, Switzerland) · 2024Review
- Broad-spectrum resistance gene RPW8.1 balances immunity and growth via feedback regulation of WRKYs.Plant biotechnology journal · 2024Article
- Discovery of candidate genes involved in ethylene biosynthesis and signal transduction pathways related to peach bud cold resistance.Frontiers in genetics · 2024Article
- Laminarin-triggered defence responses are geographically dependent in natural populations of Solanum chilense.Journal of experimental botany · 2023Article
- Linking plant functional genes to rhizosphere microbes: a review.Plant biotechnology journal · 2023Review
- Osa-miR160a confers broad-spectrum resistance to fungal and bacterial pathogens in rice.The New phytologist · 2022Article
- Induction of distinct plant cell death programs by secreted proteins from the wheat pathogen Zymoseptoria tritici.Scientific reports · 2022Article
- Interplay between phytohormone signalling pathways in plant defence - other than salicylic acid and jasmonic acid.Essays in biochemistry · 2022Article
- Microscopic and Transcriptomic Comparison of Powdery Mildew Resistance in the Progenies ofInternational journal of molecular sciences · 2022Article
- PAMP-triggered genetic reprogramming involves widespread alternative transcription initiation and an immediate transcription factor wave.The Plant cell · 2022Article
- Metatranscriptomics captures dynamic shifts in mycorrhizal coordination in boreal forests.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification and Characterization ofInternational journal of molecular sciences · 2022Article
- A Novel Guanine Elicitor Stimulates Immunity inFrontiers in plant science · 2022Article
- Fine-Tuning Roles of Osa-miR159a in Rice Immunity Against Magnaporthe oryzae and Development.Rice (New York, N.Y.) · 2021Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis RESISTANCE TO POWDERY MILDEW 8.1 (RPW8.1) activates confined cell death and defense against different pathogens. However, the underlying regulatory mechanisms still remain elusive. Here, we show that RPW8.1 activates ethylene signaling that, in turn, negatively regulates RPW8.1 expression. RPW8.1 binds and stabilizes 1-aminocyclopropane-1-carboxylate oxidase 4 (ACO4), which may in part explain increased ethylene production and signaling in RPW8.1-expressing plants. In return, ACO4 and other key components of ethylene signaling negatively regulate RPW8.1-mediated cell death and disease resistance via suppressing RPW8.1 expression. Loss of function in ACO4, EIN2, EIN3 EIL1, ERF6, ERF016 or ORA59 increases RPW8.1-mediated cell death and defense response. By contrast, overexpression of EIN3 abolishes or significantly compromises RPW8.1-mediated cell death and disease resistance. Furthermore, ERF6, ERF016 and ORA59 appear to act as trans-repressors of RPW8.1, with OAR59 being able to directly bind to the RPW8.1 promoter. Taken together, our results have revealed a feedback regulatory circuit connecting RPW8.1 and the ethylene-signaling pathway, in which RPW8.1 enhances ethylene signaling, and the latter, in return, negatively regulates RPW8.1-mediated cell death and defense response via suppressing RPW8.1 expression to attenuate its defense activity.
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