ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021
Outcomes following liver transplantation in young infants: Data from the SPLIT registry.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival and Complication of Liver Transplantation in Infants: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Night-Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial.Clinical pharmacology and therapeutics · 2025Trial
- Article
- Impact of Donor Age on Short-Term Outcomes After Pediatric Split Liver Transplantation.Pediatric transplantation · 2026Article
- Long-term outcomes of liver transplantation in biliary atresia: a 20-year single-center study.Pediatric surgery international · 2026Article
- Risk factors of pleural effusion in post-liver transplant pediatric population.Pakistan journal of medical sciences · 2026Article
- Sequential treatment strategy for biliary atresia: Kasai hepatoportoenterostomy-liver transplantation: a single-center retrospective comparative cohort study.BMC pediatrics · 2025Article
- Initiating a paediatric living donor liver transplant program in a resource-challenged environment: outcomes and lessons learned.Pediatric surgery international · 2025Article
- Chinese clinical practice guidelines for pediatric split liver transplantation.Liver research (Beijing, China) · 2024Article
- Is there a role for extracorporeal membrane oxygenation in children with acute liver failure? A retrospective analysis of the Extracorporeal Life Support Organization Registry.European journal of pediatrics · 2024Article
- Impact of donor age on short-term outcomes after pediatric split liver transplantation.Frontiers in pediatrics · 2023Article
- Secondary Malnutrition and Nutritional Intervention in Cholestatic Liver Diseases in Infants.Frontiers in nutrition · 2021Review
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Authors and funding
9 authors.
Funding
Abstract
Liver transplantation (LT) in young patients is being performed with greater frequency. We hypothesized that objective analysis of pre-, intra-, and postoperative events would help understand contributors to successful outcomes and guide transplant decision processes. We queried SPLIT registry for pediatric transplants between 2011 and 2018. Outcomes were compared for age groups: 0-<3, 3-<6, 6-<12 months, and 1-<3 years (Groups A, B, C, D respectively) and by weight categories: <5, 5-10, >10 kg; 1033 patients were available for analysis. Cholestatic disease and fulminant failure were highest in group A and those <5 kg; and biliary atresia in group C (72.8%). Group A had significantly higher life support dependence (34.6%; P < .001), listing as United Network for Organ Sharing status 1a/1b (70.4%; P < .001), and shortest wait times (P < .001). The median (interquartile range) for international normalized ratio and bilirubin were highest in group A (3.0 [2.1-3.9] and 16.7 [6.8-29.7] mg/dL) and those <5 kg (2.6 [1.8-3.4] and 13.5 [3.0-28.4] mg/dL). A pediatric end -stage liver disease score ≥40, postoperative hospital stays, rejection, and nonanastomotic biliary strictures were highest in group A with lowest survival at 93.1%. Infants 0 to <3 months and those <5 kg need more intensive care with lower survival and higher complications. Importantly, potential LT before reaching status 1a/1b and aggressive postoperative management may positively influence their outcomes.
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