Evidence map›Paper›PMID 32767563›Full record

ReviewBritish journal of pharmacology2020

Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

Detlef Obal, Joseph C Wu

Open access · bronzeAbstract readReview
In one paragraph

Review in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Adverse Impact of Cannabis on Human Health.Annual review of medicine · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Detlef ObalStanford Cardiovascular Institute, Stanford University, Stanford, California, USA.ORCID 0000-0002-1126-2132
Joseph C WuStanford Cardiovascular Institute, Stanford University, Stanford, California, USA.ORCID 0000-0002-6068-8041
Cardiovascular Institute of the South · USOutcomes Research Consortium · US

Funding

Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated CardiomyopathyR01HL141371 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$6.2M
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic CardimyopathyR01HL146690 · NHLBI · STANFORD UNIVERSITY · PI LIAO, RONGLIH, MERCOLA, MARK · 2019 to 2025
$5.1M
Effect of Microgravity on Drug Responses Using Engineered Heart TissuesUH3TR002588 · NCATS · STANFORD UNIVERSITY · PI PRUITT, BETH L, WU, JOSEPH C. · 2020 to 2022
$1.6M
Burroughs Wellcome Foundation IRSA 1015009NCATS NIH HHS UH3 TR002588NHLBI NIH HHS R01 HL141371NHLBI NIH HHS R01 HL146690Stanford Cardiovascular Institute Seed grantTobacco-related Disease Research Pogram (TRDRP) 27IR-0012Transdisciplinary Initiatives Program (TIP) Award, Stanford Maternal & Child Health Research Institute
6 · The paper itself

Abstract

Recent advances in human induced pluripotent stem cell (iPSC) technology may provide unprecedented opportunities to study patient-specific responses to anaesthetics and opioids. In this review, we will (1) examine the advantages and limitations of iPSC technology, (2) summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular system and central nervous system (CNS), and (3) describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies with reduced or minimal detrimental cardiovascular effects.

Indexed as

AnestheticsInduced Pluripotent Stem CellsAnalgesics, OpioidCell DifferentiationHumansAnalgesics, OpioidAnestheticsanaestheticsbraincardiomyocyteiPSCketamineopioidspropofol

Identifiers

PMID32767563
PMCPMC7520445
OpenAlexW3047765467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.