Evidence map›Paper›PMID 32767537›Full record

ArticleChembiochem : a European journal of chemical biology2020

Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs.

Nils Janson, Tobias Krüger, Lennard Karsten, Mareile Boschanski, Thomas Dierks, Kristian M Müller, Norbert Sewald

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. A Fluorogenic Hydrazino-Pictet-Spengler Reaction in Live Cells.Angewandte Chemie (International ed. in English) · 2025
    Article
  2. Promiscuous Enzymes for Residue-Specific Peptide and Protein Late-Stage Functionalization.Chembiochem : a European journal of chemical biology · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Bivalent EGFR-Targeting DARPin-MMAE Conjugates.International journal of molecular sciences · 2022
    Article
  8. Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs.Chembiochem : a European journal of chemical biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nils JansonFaculty of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID 0000-0002-9681-5698
Tobias KrügerFaculty of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Lennard KarstenCellular and Molecular Biotechnology, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Mareile BoschanskiFaculty of Chemistry, Biochemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Thomas DierksFaculty of Chemistry, Biochemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Kristian M MüllerCellular and Molecular Biotechnology, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID 0000-0002-7914-0625
Norbert SewaldFaculty of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID 0000-0002-0309-2655
Bielefeld University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formylglycine-generating enzymes specifically oxidize cysteine within the consensus sequence CxPxR to C

Indexed as

AzidesCross-Linking ReagentsErbB ReceptorsFluorescent DyesGlycineHumansMolecular StructureOptical ImagingTumor Cells, CulturedAzidesCross-Linking ReagentsErbB ReceptorsFluorescent DyesGlycineN-formylglycinebioconjugationbranched PEG linkerclick chemistryformylglycineHIPS ligationKnoevenagel ligation

Identifiers

PMID32767537
PMCPMC7756428
OpenAlexW3048155269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.