ArticleMagnetic resonance in medicine2021
Quantitative perfusion mapping with induced transient hypoxia using BOLD MRI.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Whole-brain BOLD responses to graded hypoxic challenges at 7 T, 9.4 T, and 15.2 T: Implications for ultrahigh-field functional and dynamic susceptibility contrast MRI.Magnetic resonance in medicine · 2025Article
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion.Neurophotonics · 2024Article
- Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin.Scientific reports · 2024Article
- Contrast-free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges.NMR in biomedicine · 2024Article
- Non-invasive perfusion MR imaging of the human brain via breath-holding.Scientific reports · 2024Article
- Mapping cerebral perfusion in mice under various anesthesia levels using highly sensitive BOLD MRI with transient hypoxia.Science advances · 2024Article
- Hypoxia-informed RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2024Article
- Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study.Frontiers in physiology · 2024Article
- Comparison of Methemoglobin, Deoxyhemoglobin, and Ferrous Nitrosyl Hemoglobin as Potential MRI Contrast Agents.Annals of biomedical engineering · 2023Article
- Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.Magnetic resonance imaging · 2023Article
- Functional magnetic resonance imaging reveals dysfunction of the paraspinal muscles in patients with chronic low back pain: a cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- Investigations of hypoxia-induced deoxyhemoglobin as a contrast agent for cerebral perfusion imaging.Human brain mapping · 2023Article
- DSC MRI in the human brain using deoxyhemoglobin and gadolinium-Simulations and validations at 3T.Frontiers in neuroimaging · 2023Article
- Sinusoidal COFrontiers in physiology · 2023Article
- Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent.Frontiers in physiology · 2023Article
- Whole-brain perfusion mapping in mice by dynamic BOLD MRI with transient hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Review
- Feasibility of glioblastoma tissue response mapping with physiologic BOLD imaging using precise oxygen and carbon dioxide challenge.Magma (New York, N.Y.) · 2022Article
- Brain metastases: the role of clinical imaging.The British journal of radiology · 2022Review
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeGadolinium-based dynamic susceptibility contrast (DSC) is commonly used to characterize blood flow in patients with stroke and brain tumors. Unfortunately, gadolinium contrast administration has been associated with adverse reactions and long-term accumulation in tissues. In this work, we propose an alternative deoxygenation-based DSC (dDSC) method that uses a transient hypoxia gas paradigm to deliver a bolus of paramagnetic deoxygenated hemoglobin to the cerebral vasculature for perfusion imaging.
methodsThrough traditional DSC tracer kinetic modeling, the MR signal change induced by this hypoxic bolus can be used to generate regional perfusion maps of cerebral blood flow, cerebral blood volume, and mean transit time. This gas paradigm and blood-oxygen-level-dependent (BOLD)-MRI were performed concurrently on a cohort of 66 healthy and chronically anemic subjects (age 23.5 ± 9.7, female 64%).
resultsOur results showed reasonable global and regional agreement between dDSC and other flow techniques, such as phase contrast and arterial spin labeling.
conclusionIn this proof-of-concept study, we demonstrated the feasibility of using transient hypoxia to generate a contrast bolus that mimics the effect of gadolinium and yields reasonable perfusion estimates. Looking forward, optimization of the hypoxia boluses and measurement of the arterial-input function is necessary to improve the accuracy of dDSC. Additionally, a cross-validation study of dDSC and DSC in brain tumor and ischemic stroke subjects is warranted to evaluate the clinical diagnostic utility of this approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.