ArticleEvolution; international journal of organic evolution2020
Fly wing evolution explained by a neutral model with mutational pleiotropy.
Article in Evolution; international journal of organic evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Apparent stabilizing selection explains micro- and macroevolution of Drosophila wings.Nature ecology & evolution · 2026Article
- Persistent selection on size explains micro- and macroevolutionary alignments in fly wings.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A simple model reveals why complex evolutionary innovations follow predictable paths.bioRxiv : the preprint server for biology · 2025Article
- Developmental lines of least resistance predict standing genetic covariation but do not constrain plasticity or rapid evolution.Proceedings. Biological sciences · 2025Article
- Alternative Mutational Architectures Producing Identical M-Matrices can Lead to Different Patterns of Evolutionary Divergence.Genome biology and evolution · 2025Article
- Macroevolution along developmental lines of least resistance in fly wings.Nature ecology & evolution · 2025Article
- Evaluating the Performance of Widely Used Phylogenetic Models for Gene Expression Evolution.Genome biology and evolution · 2023Article
- Patterns and evolutionary consequences of pleiotropy.Annual review of ecology, evolution, and systematics · 2023Article
- Evaluating the Performance of Widely Used Phylogenetic Models for Gene Expression Evolution.bioRxiv : the preprint server for biology · 2023Article
- On the Decoupling of Evolutionary Changes in mRNA and Protein Levels.Molecular biology and evolution · 2023Article
- Developmental bias predicts 60 million years of wing shape evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Decoupling of evolutionary changes in mRNA and protein levels.bioRxiv : the preprint server for biology · 2023Article
- Evolvability and trait function predict phenotypic divergence of plant populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolvability and constraint in the evolution of three-dimensional flower morphology.American journal of botany · 2022Article
- Frequent origins of traumatic insemination involve convergent shifts in sperm and genital morphology.Evolution letters · 2022Article
- Natural selection mediated by seasonal time constraints increases the alignment between evolvability and developmental plasticity.Evolution; international journal of organic evolution · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To what extent the speed of mutational production of phenotypic variation determines the rate of long-term phenotypic evolution is a central question. Houle et al. recently addressed this question by studying the mutational variances, additive genetic variances, and macroevolution of locations of vein intersections on fly wings, reporting very slow phenotypic evolution relative to the rates of mutational input, high phylogenetic signals, and a strong, linear relationship between the mutational variance of a trait and its rate of evolution. Houle et al. found no existing model of phenotypic evolution to be consistent with all these observations, and proposed the improbable scenario of equal influence of mutational pleiotropy on all traits. Here, we demonstrate that the purported linear relationship between mutational variance and evolutionary divergence is artifactual. We further show that the data are explainable by a simple model in which the wing traits are effectively neutral at least within a range of phenotypic values but their evolutionary rates are differentially reduced because mutations affecting these traits are purged owing to their different pleiotropic effects on other traits that are under stabilizing selection. Thus, the evolutionary patterns of fly wing morphologies are explainable under the existing theoretical framework of phenotypic evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.