Evidence map›Paper›PMID 32767227›Full record

Trial reportNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

Emerging Clinical Technology: Application of Machine Learning to Chronic Pain Assessments Based on Emotional Body Maps.

Pavel Goldstein, Yoni Ashar, Jonas Tesarz, Mehmet Kazgan, Burak Cetin, Tor D Wager

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07081737 (The Future of Pain Management), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07081737 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Future of Pain Management: Can Person-centred and Precision AI-Based Decision Support Enhance Interdisciplinary Rehabilitation for Chronic Pain?

TypeinterventionalSponsorBjorn AngRan2026 to 2029Enrolled400ConditionsPain, Chronic, Chronic Pain, Widespread, Pain ManagementArmsInterdisciplinary treatment (IDT) + Clinical Decision Support System (CDSS), Interdisciplinary treatment (IDT)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Emotional recognition technologies applied to health: review and challenges.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Applications of Artificial Intelligence in Pain Medicine.Current pain and headache reports · 2024
    Review
  12. The use of Arts-Based Research in Chronic Pain: A Scoping Review.Canadian journal of pain = Revue canadienne de la douleur · 2024
    Article
  13. Article
  14. Using artificial intelligence to improve pain assessment and pain management: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Aligning New Approaches to Accelerate the Development of Non-opioid Analgesic Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Pavel GoldsteinThe School of Public Health, University of Haifa, Haifa, Israel. pavelg@stat.haifa.ac.il.ORCID http://orcid.org/0000-0002-5224-1725
Yoni AsharWeill Cornell Medical College, New York, NY, USA.
Jonas TesarzDepartment for General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.
Mehmet Kazgancliexa, Denver, CO, USA.
Burak Cetincliexa, Denver, CO, USA.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA. tor.d.wager@dartmouth.edu.
Colorado Latino Leadership, Advocacy & Research Organization · USCornell University · USDartmouth College · USHeidelberg University · DEUniversity of Haifa · IL

Funding

The Neural Bases of Placebo Effects and their Relation to Regulatory ProcessesR01MH076136 · NIMH · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2007 to 2023
$8.5M
Brain and Genetic Predictors of Individual Differences in Pain and Placebo AnalgesiaR01DA046064 · NIDA · UNIVERSITY OF COLORADO · PI FRIEDMAN, NAOMI P., WAGER, TOR D. · 2018 to 2022
$3.2M
fMRI-based Biomarkers for Multiple Components of PainR01DA035484 · NIDA · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2013 to 2017
$3.1M
NIDA NIH HHS R01 DA035484NIDA NIH HHS R01 DA046064NIMH NIH HHS R01 MH076136
6 · The paper itself

Abstract

Depression and anxiety co-occur with chronic pain, and all three are thought to be caused by dysregulation of shared brain systems related to emotional processing associated with body sensations. Understanding the connection between emotional states, pain, and bodily sensations may help understand chronic pain conditions. We developed a mobile platform for measuring pain, emotions, and associated bodily feelings in chronic pain patients in their daily life conditions. Sixty-five chronic back pain patients reported the intensity of their pain, 11 emotional states, and the corresponding body locations. These variables were used to predict pain 2 weeks later. Applying machine learning, we developed two predictive models of future pain, emphasizing interpretability. One model excluded pain-related features as predictors of future pain, and the other included pain-related predictors. The best predictors of future pain were interactive effects of (a) body maps of fatigue with negative affect and (b) positive affect with past pain. Our findings emphasize the contribution of emotions, especially emotional experience felt in the body, to understanding chronic pain above and beyond the mere tracking of pain levels. The results may contribute to the generation of a novel artificial intelligence framework to help in the development of better diagnostic and therapeutic approaches to chronic pain.

Indexed as

EmotionsAdultAgedBack PainBiomedical TechnologyChronic PainFemaleHumansMachine LearningMaleMiddle AgedPain MeasurementYoung Adultbodily sensation mapChronic painemotionsinteroceptionlow back painpain assessment

Identifiers

PMID32767227
PMCPMC7609511
OpenAlexW3048221799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.