Evidence map›Paper›PMID 32767222›Full record

ArticleMolecular biology reports2020

Hybrid of niosomes and bio-synthesized selenium nanoparticles as a novel approach in drug delivery for cancer treatment.

Mahmoud Gharbavi, Behrooz Johari, Navid Mousazadeh, Bahareh Rahimi, Milad Parvinzad Leilan, Seyed Sadegh Eslami, Ali Sharafi

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  11. Insights into the molecular response ofScience and technology of advanced materials · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahmoud GharbaviStudent Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran.ORCID http://orcid.org/0000-0002-9580-1999
Behrooz JohariDepartment of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. dr.johari@zums.ac.ir.ORCID http://orcid.org/0000-0003-3440-572X
Navid MousazadehDepartment of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Bahareh RahimiDepartment of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-0208-555X
Milad Parvinzad LeilanDepartment of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.ORCID https://orcid.org/0000-0003-4493-2806
Seyed Sadegh EslamiDepartment of Genetics and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Ali SharafiZanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Sharafi.a@gmail.com.ORCID http://orcid.org/0000-0002-6012-1424

Funding

Zanjan University of Medical Sciences Grant Number: A-12-1244-11 & Ethical Code: IR.ZUMS.REC.1398.438
6 · The paper itself

Abstract

The current study intends to investigate a novel drug delivery system (DDS) based on niosomes structure (NISM) and bovine serum albumin (BSA) which was formulated to BSA coated NISM (NISM-B). Also, selenium nanoparticles (SeNPs) have been prepared by BSA mediated biosynthesis. Finally, the NISM-B was hybridized with SeNPs and was formulated as NISM-B@SeNPs for drug delivery applications. Physicochemical properties of all samples were characterized by UV-Vis spectroscopy, FT-IR, DLS, FESEM, and EDX techniques. The cytotoxicity of all samples against A549 cell line was assessed by cell viability analysis and flow cytometry for apoptotic cells as well as RT-PCR for the expression of MDR-1, Bax, and Bcl-2 genes. Besides, in vivo biocompatibility was performed by LD

Indexed as

A549 CellsApoptosisATP Binding Cassette Transporter, Subfamily Bbcl-2-Associated X ProteinCell SurvivalDrug CarriersDrug Delivery SystemsDynamic Light ScatteringHumansLiposomesMaterials TestingMicroscopy, Electron, ScanningNanoparticlesParticle SizeProto-Oncogene Proteins c-bcl-2RheologyABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BBAX protein, humanbcl-2-Associated X ProteinDrug CarriersLiposomesProto-Oncogene Proteins c-bcl-2SeleniumSerum Albumin, BovineAlbuminBiosynthesisBSADrug deliveryNiosomesSelenium nanoparticles

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.