ArticleVirologica Sinica2021
A Novel Vibriophage vB_VcaS_HC Containing Lysogeny-Related Gene Has Strong Lytic Ability against Pathogenic Bacteria.
Article in Virologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- Genomic characterization and phage cocktail suppression of a multidrug-resistantApplied and environmental microbiology · 2026Article
- Mining a vibriophage depolymerase for enhanced pathogen control in aquaculture.Applied and environmental microbiology · 2026Article
- A novel phage vB_VhaM_HVS-1 inhibits host cell associatedFrontiers in veterinary science · 2026Article
- Enhanced control of pathogenicApplied and environmental microbiology · 2025Article
- Two novel polyvalent phages: a promising approach for cross-order pathogen control in aquaculture.Virology journal · 2025Article
- Isolation, complete characterization and phylogeography of the first bacteriophage againstMicrobial genomics · 2025Article
- Lysin and Lytic Phages Reduce Vibrio Counts in Live Feed and Fish Larvae.Microorganisms · 2024Article
- Bacteriophage EPP-1, a potential antibiotic alternative for controlling edwardsiellosis caused by Edwardsiella piscicida while mitigating drug-resistant gene dissemination.Scientific reports · 2024Article
- Biologic and genomic characterization of a novel virulentFrontiers in veterinary science · 2024Article
- The trade-off ofFrontiers in microbiology · 2024Article
- Characterization of a Vibriophage Infecting PathogenicInternational journal of molecular sciences · 2023Article
- Review
- Genome Characterization and Infectivity Potential of Vibriophage-ϕLV6 with Lytic Activity against Luminescent Vibrios ofViruses · 2023Article
- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- Isolation and Characterization of a Newly Discovered Phage, V-YDF132, for Lysing Vibrio harveyiViruses · 2022Article
- Genomic and Biological Profile of a Novel Bacteriophage, Vibrio phage Virtus, Which Improves Survival ofPathogens (Basel, Switzerland) · 2022Article
- A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria.Applied and environmental microbiology · 2022Article
- A Novel Phage Indirectly Regulates Diatom Growth by Infecting a Diatom-Associated Biofilm-Forming Bacterium.Applied and environmental microbiology · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To avoid the negative effects of antibiotics, using phage to prevent animal disease becomes a promising method in aquaculture. Here, a lytic phage provisionally named vB_VcaS_HC that can infect the pathogen (i.e., Vibrio campbellii 18) of prawn was isolated. The phage has an isometric head and a non-contractile tail. During phage infection, the induced host mortality in 5.5 h reached ca. 96%, with a latent period of 1.5 h and a burst size of 172 PFU/cell. It has an 81,566 bp circular dsDNA genome containing 121 open reading frames (ORFs), and ca. 71% of the ORFs are functionally unknown. Comparative genomic and phylogenetic analysis revealed that it is a novel phage belonging to Delepquintavirus, Siphoviridae, Caudovirales. In the phage genome, besides the ordinary genes related to structure assembly and DNA metabolism, there are 10 auxiliary metabolic genes. For the first time, the pyruvate phosphate dikinase (PPDK) gene was found in phages whose product is a key rate-limiting enzyme involving Embden-Meyerhof-Parnas (EMP) reaction. Interestingly, although the phage has a strong bactericidal activity and contains a potential lysogeny related gene, i.e., the recombinase (RecA) gene, we did not find the phage turned into a lysogenic state. Meanwhile, the phage genome does not contain any bacterial virulence gene or antimicrobial resistance gene. This study represents the first comprehensive characterization of a lytic V. campbellii phage and indicates that it is a promising candidate for the treatment of V. campbellii infections.
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