Evidence map›Paper›PMID 32767183›Full record

ReviewAdvances in therapy2020

Gut Microbiota Modulation: Implications for Infection Control and Antimicrobial Stewardship.

Glorijoy Shi En Tan, Hui Lin Tay, Sock Hoon Tan, Tau Hong Lee, Tat Ming Ng, David Chien Lye

Open access · hybridAbstract readReview
In one paragraph

Review in Advances in therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  17. Drug Targeting of Inflammatory Bowel Diseases by Biomolecules.Nanomaterials (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Review
  20. Gut Microbiota Contributes to Host Defense AgainstJournal of inflammation research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Glorijoy Shi En TanNational Centre for Infectious Diseases, Singapore, Singapore.
Hui Lin TayDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
Sock Hoon TanDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
Tau Hong LeeNational Centre for Infectious Diseases, Singapore, Singapore.
Tat Ming NgDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
David Chien LyeNational Centre for Infectious Diseases, Singapore, Singapore. david_lye@ncid.sg.ORCID 0000-0003-0324-0205
Tan Tock Seng Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human microbiome comprises a complex ecosystem of microbial communities that exist within the human body, the largest and most diverse of which are found within the human intestine. It has been increasingly implicated in human health and diseases, demonstrably playing a critical role in influencing host immune response, protection against pathogen overgrowth, biosynthesis, and metabolism. As our understanding of the links between the gut microbiota with host immunity and infectious diseases deepens, there is a greater need to incorporate methods of modulating it as a means of therapy or infection prevention in daily clinical practice. Traditional antimicrobial stewardship principles have been evaluated to assess their impact on the gut microbiota diversity and the consequent repercussions, taking into consideration antibiotic pharmacokinetic and pharmacodynamic properties. Novel strategies of selective digestive decontamination and fecal microbiota transplantation to regulate the gut microbiota have also been tested in different conditions with variable results. This review seeks to provide an overview of the available literature on the modulation of the gut microbiota and its implications for infection control and antimicrobial stewardship. With increased understanding, gut microbiota profiling through metataxonomic analysis may provide further insight into modulating microbial communities in the context of infection prevention and control.

Indexed as

Antimicrobial StewardshipGastrointestinal MicrobiomeMicrobiotaFecal Microbiota TransplantationHumansInfection ControlAntimicrobial stewardshipGut MicrobiotaInfection controlInfectious diseases

Identifiers

PMID32767183
PMCPMC7412295
OpenAlexW3048099740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.