ArticleThe Journal of cell biology1988
Heterogeneity in lymphocyte spectrin distribution: ultrastructural identification of a new spectrin-rich cytoplasmic structure.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 86 citations in OpenAlex.
- Mechanical characterization of spectrin at the molecular level.Scientific reports · 2024Article
- Protein kinase C signaling and cell cycle regulation.Frontiers in immunology · 2012Article
- Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat.Journal of molecular and cellular cardiology · 2010Article
- Article
- Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.The Journal of cell biology · 2000Article
- Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles.The Journal of cell biology · 1996Article
- Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly.The Journal of cell biology · 1995Article
- Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex.The Journal of cell biology · 1994Article
- Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta.The Journal of cell biology · 1994Article
- Expression of chicken vinculin complements the adhesion-defective phenotype of a mutant mouse F9 embryonal carcinoma cell.The Journal of cell biology · 1993Article
- Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.The Journal of cell biology · 1992Article
- Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- An actin-associated protein present in the microtubule organizing center and the growth cones of PC-12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1992Article
- Actin in the Drosophila embryo: is there a relationship to developmental cue localization?BioEssays : news and reviews in molecular, cellular and developmental biology · 1991Review
- The effect of free fatty acids on spectrin organization in lymphocytes.Cell biophysics · 1990Article
- Alpha-spectrin immunoanalog in Acanthamoeba cells.Histochemistry · 1990Article
- Immunohistochemical analysis of human skin using antispectrin and anti-beta-fodrin antibodies.Archives of dermatological research · 1990Article
- Drosophila spectrin: the membrane skeleton during embryogenesis.The Journal of cell biology · 1989Article
- Induction of anti-Ro60/anti-La by immunisation with spectrin and induction of anti-spectrin by immunisation with Ro60 and 4-hydroxy-2-nonenal-modified Ro60 immunisation.Clinical and experimental rheumatologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Spectrin-like proteins are found in a wide variety of non-erythroid cells where they generally occur in the cell cortex near the plasma membrane. To determine the intracellular distribution of alpha-spectrin (alpha-fodrin) in lymphocytes, we have developed an immunoperoxidase method to localize this protein at the ultrastructural level. Of considerable interest, particularly with regard to our efforts to determine the function of spectrin in this cell type, was the finding that its subcellular localization and its relationship with the plasma membrane can vary dramatically. Based on its position in the cell, alpha-spectrin can occur in two forms in lymphocytes: one that associates closely with the plasma membrane and another that occurs at some distance from the cell periphery, either as a single large aggregate or as several smaller ones. The single large aggregate of spectrin is a stable feature in a number of lymphocyte cell lines and hybrids which were used to examine its ultrastructural characteristics. A previously undescribed cellular structure, consisting of a meshwork of spectrin filaments and membranous vesicles, was identified in these cells. This structure could be induced to dissipate in response to membrane perturbants (e.g., hyperthermia and phorbol esters, known effectors of lymphocyte function and differentiation) and the patterns resulting from the redistribution of spectrin were a reflection of those observed routinely in lymphocytes in situ. The correlation between naturally occurring spectrin localization patterns and those seen after membrane perturbation suggested the possibility that spectrin distribution is indicative of particular maturation stages or functional states in lymphocytes. The implications of these findings with regard to the role of spectrin in lymphocyte function are discussed.
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