ArticleSkeletal radiology2021
Use of routine computed tomography scans for detecting osteoporosis in thoracolumbar vertebral bodies.
Article in Skeletal radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07739628 (Prospective Clinical Validation Study of a Deep Learning Model for Opportunistic Osteoporosis Screening Based on Non-Contrast CT Scans), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Clinical Validation Study of a Deep Learning Model for Opportunistic Osteoporosis Screening Based on Non-Contrast CT Scans
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Prediction of Osteoporosis at the Sacrum Using Opportunistic CT of the Abdomen and Pelvis: A Retrospective Feasibility Study in 277 Patients Comparing CT and QCT Data.Journal of clinical medicine · 2026Article
- Diagnostic performance of lumbar computed tomography Hounsfield unit thresholds for osteoporosis and osteopenia: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Deep learning model for osteoporosis screening on chest CT with low tube voltage.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Incidence and risk factors for cardiac arrest following upper cervical spine fractures in the elderly after minor trauma.Archives of orthopaedic and trauma surgery · 2026Article
- Evaluating Bone Mass with Opportunistic Chest CT: T8 as the Optimal Vertebral Level.Calcified tissue international · 2025Article
- Comparison of thoracic vertebrae and L1 CT attenuation in predicting osteoporosis using opportunistic chest CT.Therapeutic advances in musculoskeletal disease · 2025Article
- Unsupervised Clustering of Vertebral Hounsfield Units in Opportunistic Chest CT for Stratifying Bone Mass Subtypes in a 2 Years' Period.Clinical interventions in aging · 2025Article
- Long-term effects of COVID-19 infection on bone mineral density.Journal of global health · 2024Article
- The influence of proliferative tissue on Hounsfield unit and its correlation with BMD in middle-aged and elderly patients with lumbar degenerative diseases.Journal of orthopaedic surgery and research · 2024Article
- Utilizing radiomics techniques to isolate a single vertebral body from chest CT for opportunistic osteoporosis screening.BMC musculoskeletal disorders · 2024Article
- Value of Hounsfield units measured by chest computed tomography for assessing bone density in the thoracolumbar segment of the thoracic spine.Asian spine journal · 2024Article
- Diagnostic Value of Hounsfield Units for Osteoporotic Thoracolumbar Vertebral Non-Compression Fractures in Elderly Patients with Low-Energy Injuries.International journal of general medicine · 2024Article
- The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography.Clinical interventions in aging · 2024Article
- Vertebral CT attenuation outperforms standard clinical fracture risk prediction tools in detecting osteoporotic disease in lung cancer screening participants.The British journal of radiology · 2023Article
- Performance of iCare quantitative computed tomography in bone mineral density assessment of the hip and vertebral bodies in European spine phantom.Journal of orthopaedic surgery and research · 2023Article
- The Use of Intraoperative CT Hounsfield Unit Values for the Assessment of Bone Quality in Patients Undergoing Lumbar Interbody Fusion.Global spine journal · 2023Article
- Opportunistic screening at chest computed tomography: literature review of cardiovascular significance of incidental findings.Cardiovascular diagnosis and therapy · 2023Review
- Routine chest CT combined with the osteoporosis self-assessment tool for Asians (OSTA): a screening tool for patients with osteoporosis.Skeletal radiology · 2023Article
- Diagnostic Accuracy of Dual-Energy CT Material Decomposition Technique for Assessing Bone Status Compared with Quantitative Computed Tomography.Diagnostics (Basel, Switzerland) · 2023Article
- Addressing gaps in osteoporosis screening in kuwait using opportunistic quantitative computer tomography (QCT): a retrospective study.Archives of osteoporosis · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study observed the distribution of CT attenuation values for T10-L3 vertebral bodies and derived the Hounsfield unit (HU) thresholds using the quantitative computed tomography (QCT) as a reference to predict osteoporosis and normal bone density.
methodsWe included 482 subjects who were scheduled to undergo CT lung cancer screening and pulmonary nodule follow-up from May 2015 to February 2019. The subjects were scanned with the calibration phantom beneath the back while performing a chest CT scan. The volumetric bone mineral density (vBMD) and CT attenuation values of T10-L3 vertebral bodies were measured, and the correlation between the two measurements was analyzed. Receiver operator characteristic (ROC) curves were generated to determine diagnostic optimal thresholds.
resultsA total of 2716 vertebral bodies of 457 participants were measured after exclusion screening. CT attenuation value of each plane's vertebral body showed a strong correlation with vBMD. The optimal threshold of > 141 HU was 93.5% sensitive and 86.1% specific for the recognition of normal BMD. The optimal threshold of < 102.4 HU was 96.9% specific and 82.1% sensitive for distinguishing osteoporosis from osteopenia and normal BMD. The average CT attenuation values of vertebral bodies with compressed and normal morphology were 108.9 ± 20.6 and 136.8 ± 32.2 HU, respectively.
conclusionSagittal reconstruction of the thoracic vertebrae using routine thoracic CT image combined with CT attenuation value measurements of the spine is valuable for predicting bone mineral density in high-risk populations. The mean CT attenuation values of the vertebral bodies with vertebral compression appearance were lower than that of normal vertebral shape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.