Evidence map›Paper›PMID 32767048›Full record

ArticleBrain imaging and behavior2021

Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates.

Flóra John, Sharon K Michelhaugh, Geoffrey R Barger, Sandeep Mittal, Csaba Juhász

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02367469 (Tryptophan Metabolism in Human Brain Tumors), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.1field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02367469 completednot on this map

Tryptophan Metabolism in Human Brain Tumors

TypeobservationalSponsorWayne State UniversityRan2014 to 2021Enrolled105ConditionsBrain Tumors
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Tryptophan metabolism in brain tumors - IDO and beyond.Current opinion in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Flóra JohnDepartment of Pediatrics, Wayne State University and PET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, 3901 Beaubien St, MI, Detroit, 48201, USA.
Sharon K MichelhaughDepartment of Neurosurgery, Wayne State University, 4201 St. Antoine St., Detroit, MI, 48201, USA.
Geoffrey R BargerDepartment of Neurology, Wayne State University, 4201 St. Antoine St, Detroit, MI, 48201, USA.
Sandeep MittalDepartment of Neurosurgery, Wayne State University, 4201 St. Antoine St., Detroit, MI, 48201, USA.
Csaba JuhászDepartment of Pediatrics, Wayne State University and PET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, 3901 Beaubien St, MI, Detroit, 48201, USA. csaba.juhasz@wayne.edu.
Wayne State University · USThe Barbara Ann Karmanos Cancer Institute · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
Tryptophan Metabolism in Human Brain TumorsR01CA123451 · NCI · WAYNE STATE UNIVERSITY · PI JUHASZ, CSABA, MITTAL, SANDEEP · 2008 to 2018
$3.1M
NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA123451
6 · The paper itself

Abstract

Patients with brain tumors have an increased risk for depression, whose underlying pathomechanism may involve dysregulated tryptophan/kynurenine metabolism. In this study, we analyzed the relation of depressive symptoms to clinical and tumor characteristics as well as cerebral and systemic tryptophan metabolism in patients with primary brain tumors. Sixty patients with newly-diagnosed or recurrent primary brain tumor underwent testing with the Beck Depression Inventory-II (BDI-II), and 34 patients also had positron emission tomography (PET) imaging with alpha-[

Indexed as

Brain NeoplasmsTryptophanDepressionHumansMagnetic Resonance ImagingMolecular ImagingNeoplasm Recurrence, LocalTryptophanBrain tumorDepressionKynurenine pathwayPETSerotoninTryptophan

Identifiers

PMID32767048
PMCPMC7865029
OpenAlexW3048286462

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.