Evidence map›Paper›PMID 32766961›Full record

ArticleCardiology and therapy2020

The Effect of Low-Dose Ticagrelor on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad: The TWIST Pilot Study.

Naveen Seecheran, Brent Boodhai, Aarti Maharaj, Arvinash Ramdeen, Niranjan Debideen, Vishesh Ochalal, Randall Singh, Rajeev Seecheran, Valmiki Seecheran, Sangeeta Persad and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04206176 (The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04206176 phase1 / phase2completednot on this map

The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease: TWIST Trial

TypeinterventionalSponsorThe University of The West IndiesRan2019 to 2020Enrolled25ConditionsPlatelet Dysfunction Due to DrugsArmsTicagrelor
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Naveen SeecheranThe University of the West Indies, St. Augustine, Port of Spain, Trinidad and Tobago. naveen.seecheran@sta.uwi.edu.ORCID http://orcid.org/0000-0002-7779-0181
Brent BoodhaiNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Aarti MaharajNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Arvinash RamdeenNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Niranjan DebideenNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Vishesh OchalalNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Randall SinghNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Rajeev SeecheranNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Valmiki SeecheranNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Sangeeta PersadNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Harun AbdullahNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Lakshmipathi PeramNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Shastri MotilalNorth Central Regional Health Authority, Champs Fleurs, Mount Hope, Trinidad and Tobago.
Antonio Tello-MontoliuUniversidad de Murcia, Murcia, Spain.
David SchneiderCardiovascular Research Institute of Vermont, Colchester, Vermont, USA.
Caribbean Health Research Council · TTUniversidad de Murcia · ESUniversity of the West Indies · TT

Funding

University of the West Indies, St. Augustine Campus Campus ResearchUniversity of the West Indies, St. Augustine Campus Publication Fund (CRP.4MAR16.38(3)) from the University of the West Indies, St. Augustine for TTD 22,125.
6 · The paper itself

Abstract

introductionThis prospective, pharmacodynamic study aimed to explore the potential applicability of a low-dose ticagrelor regimen in a heterogeneous Trinidadian subpopulation.

methodsPatients with stable coronary artery disease (n = 25) who were actively treated with dual antiplatelet therapy of aspirin 81 mg daily and clopidogrel 75 mg daily were recruited. Platelet function was measured with the VerifyNow P2Y

resultsThe mean P2Y

conclusionsSignificantly attenuated platelet reactivity was seen on the low ticagrelor maintenance dose as compared to clopidogrel. This dedicated pharmacodynamic study could be applicable and informative for Trinidadian stable coronary artery disease patients. Further studies are required to confirm these exploratory findings.(Funded by the University of the West Indies, St. Augustine).

trial registrationClinicalTrials.gov number NCT04206176.

Indexed as

ClopidogrelHigh on-treatment platelet reactivityTicagrelorVerifyNow

Identifiers

PMID32766961
PMCPMC7584691
OpenAlexW3047368243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.