ArticleFamily practice2021
Patterns of multimorbidity and pharmacotherapy: a total population cross-sectional study.
Article in Family practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- A systematic review and meta-analysis of disease clusters in multimorbidity.Nature communications · 2025Pooled it
- Specific content for collaborative care: a systematic review of collaborative care interventions for patients with multimorbidity involving depression and/or anxiety in primary care.Family practice · 2022Pooled it
- The Health and Life in Balance intervention to improve patient capacity for older people with multimorbidity: a pragmatic mixed methods non-randomised pilot study.BMC primary care · 2025Trial
- Article
- The Association Between Number of Chronic Conditions and Benzodiazepine Prescribing in Region Stockholm, Sweden: A Total Population-Based Cohort Study.Health science reports · 2026Article
- Multiple Chronic Conditions and Multimorbidity Among Older Adults in Southern Albania: Distribution and Impact on Care Needs, Medication Adherence, and Quality of Life.Healthcare (Basel, Switzerland) · 2026Article
- A machine learning model to simplify recognition of patients with atrial fibrillation based on diagnostic codes in Swedish primary health care.BMC medical informatics and decision making · 2026Article
- Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.JACC. Advances · 2026Article
- LipidSnapshot - Treatment gaps in hypercholesterolemia in patients with atherosclerotic cardiovascular disease documented by office-based cardiologists and general practitioners in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Causal knowledge graph analysis identifies adverse drug effects.Bioinformatics (Oxford, England) · 2026Article
- "So I call myself healthy": a qualitative study on health perceptions and healthcare experiences in older adults with multimorbidity.BMC primary care · 2025Article
- Experiences from Sweden on developing evidence-based care for the primary care population.Scandinavian journal of primary health care · 2025Article
- The most common diagnoses in primary care, and changes over time, in the total population of Stockholm, Sweden.BMC primary care · 2025Article
- Multimorbidity Management: A Scoping Review of Interventions and Health Outcomes.International journal of environmental research and public health · 2025Article
- Article
- Exploring patterns of multimorbidity in South Korea using exploratory factor analysis and non negative matrix factorization.Scientific reports · 2025Article
- Sociodemographic characteristics and health status of women with breast cancer and COVID 19 diagnosis by menopausal status a cross sectional study.Scientific reports · 2025Article
- Statin treatment for primary and secondary prevention in elderly patients-a cross-sectional study in Stockholm, Sweden.European journal of clinical pharmacology · 2024Article
- Protocol for the development and validation of a Polypharmacy Assessment Score.Diagnostic and prognostic research · 2024Article
- Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden.Aging cell · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of multimorbid patients can be improved. Development of patient-centred care of high-quality requires context-bound understanding of the multimorbid population's patterns of demographics, co-morbidities and medication use.
objectiveThe aim of this study was to identify patterns of multimorbidity in the total population of Region Stockholm, Sweden, by exploring demographics, claimed prescription drugs, risk of mortality and non-random association of conditions.
methodsIn this cross-sectional descriptive population-based cohort study, we extracted data from the Swedish VAL database (N = 2 323 667) including all consultations in primary and specialized outpatient care, all inpatient care and all prescriptions claimed during 2017. We report number of chronic conditions and claimed prescription drugs, physical and mental co-morbidity, and 1-year mortality. We stratified the analyses by sex. We examined non-random associations between diseases using cluster analysis.
resultsIn total, 21.6% had multimorbidity (two or more chronic conditions) and 24.1% had polypharmacy (more than five claimed prescription drugs). Number of claimed drugs, co-occurrence of mental and physical conditions, and 1-year mortality increased as multimorbidity increased. We identified seven multimorbidity clusters with clinically distinct characteristics. The smallest cluster (7% of individuals) had prominent cardiovascular disease, the highest 1-year mortality rate, high levels of multimorbidity and polypharmacy, and was much older. The largest cluster (27% of individuals) was younger and heterogenous, with primarily mental health problems.
conclusionsIndividuals with chronic conditions often show clinical complexity with both concordant and discordant conditions and polypharmacy. This study indicates that clinical guidelines addressing clustering of conditions may be one strategy for managing complexity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.