Evidence map›Paper›PMID 32766600›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection.

Niyati Desai, Azfar Neyaz, Annamaria Szabolcs, Angela R Shih, Jonathan H Chen, Vishal Thapar, Linda T Nieman, Alexander Solovyov, Arnav Mehta, David J Lieb and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Niyati DesaiMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Azfar NeyazMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Annamaria SzabolcsMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Angela R ShihDepartment of Pathology, Boston, MA 02114, USA.
Jonathan H ChenMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Vishal ThaparMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Linda T NiemanMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Alexander SolovyovMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Arnav MehtaMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
David J LiebThe Broad Institute, Cambridge, MA 02142, USA.
Anupriya S KulkarniMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Christopher JaicksMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Christopher J PintoMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Dejan JuricMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Ivan ChebibDepartment of Pathology, Boston, MA 02114, USA.
Robert B ColvinDepartment of Pathology, Boston, MA 02114, USA.
Arthur Y KimDepartment of Medicine, Boston, MA 02114, USA.
Robert MonroeAdvanced Cell Diagnostics, a Bio-Techne Brand, Newark, CA 94560, USA.
Sarah E WarrenNanoString Inc., Seattle, WA 98109, USA.
Patrick DanaherNanoString Inc., Seattle, WA 98109, USA.
Jason W ReevesNanoString Inc., Seattle, WA 98109, USA.
Jingjing GongNanoString Inc., Seattle, WA 98109, USA.
Erroll H RueckertNanoString Inc., Seattle, WA 98109, USA.
Benjamin D GreenbaumMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Nir HacohenMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Stephen M LaganaColumbia University Irving Medical Center, Department of Pathology and Cell Biology, New York, NY 10032, USA.
Miguel N RiveraMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Lynette M ShollBrigham and Woman's Hospital, Department of Pathology, Boston, MA 02115.
James R StoneDepartment of Pathology, Boston, MA 02114, USA.
David T TingMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Vikram DeshpandeMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

Funding

Modulating anti-HIV immunity by plasmacytoid dendritic cellsR01AI081848 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHARDWAJ, NINA · 2010 to 2021
$4.5M
Understanding the Relationship of Repeat Expression and MetastasisR01CA240924 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBAUM, BENJAMIN, TING, DAVID TSAI · 2019 to 2023
$3.3M
Cancer Immunology Training GrantT32CA207021 · NCI · DANA-FARBER CANCER INST · PI WUCHERPFENNIG, KAI W · 2016 to 2020
$2.4M
NCI NIH HHS R01 CA240924NCI NIH HHS T32 CA207021NIAID NIH HHS R01 AI081848
6 · The paper itself

Abstract

The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.

Identifiers

PMID32766600
PMCPMC7402055

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.