ArticleCritical care explorations2020
Point-of-Care Analysis of Neutrophil Phenotypes: A First Step Toward Immuno-Based Precision Medicine in the Trauma ICU.
Article in Critical care explorations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Neutrophil cell surface receptor dynamics following trauma: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes.Journal of leukocyte biology · 2021Trial
- Hallmarks of the multidimensional immune response to trauma in humans.Nature immunology · 2026Review
- Neutrophil phenotyping reflects injury severity when base excess and lactate remain normal.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- High interobserver reliability of neutrophil phenotyping based on visual determination of CD16/CD62L expression patterns.Langenbeck's archives of surgery · 2026Article
- Immune cell dynamics, cytokines, and extracellular vesicles in systemic inflammatory response syndrome (SIRS): a multiparametric analysis.Journal of translational medicine · 2025Article
- Defining the early systemic neutrophil signature after severe trauma: decreased CD10/CD16 levels on admission precedes metabolic dysregulation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Exploratory Study of CD10Scandinavian journal of immunology · 2025Article
- Exploring the role of systemic inflammation in guiding clinical decision making for geriatric patients with a hip fracture.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Translating Biomarker Research into Clinical Practice in Orthopaedic Trauma: A Systematic Review.Journal of clinical medicine · 2025Review
- Neutrophil phenotypes quantify tissue damage caused by major surgery.Frontiers in surgery · 2025Article
- Time sequence of bacterial and fungal pathogens causing infections in trauma patients.Trauma surgery & acute care open · 2025Article
- Limited impact of traumatic brain injury on the post-traumatic inflammatory cellular response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- The emerging importance of skull-brain interactions in traumatic brain injury.Frontiers in immunology · 2024Review
- Identification of neutrophil phenotype categories in geriatric hip fracture patients aids in personalized medicine.OTA international : the open access journal of orthopaedic trauma · 2023Article
- Visualization of the inflammatory response to injury by neutrophil phenotype categories : Neutrophil phenotypes after trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Association Between Neutrophil Density and Survival in Trauma Patients Admitted to the Intensive Care Unit; a Retrospective Cohort Study.Archives of academic emergency medicine · 2023Article
- Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Neutrophils Contribute to Severity of Tuberculosis Pathology and Recovery From Lung Damage Pre- and Posttreatment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe amount of tissue damage and the amplitude of the immune response after trauma are related to the development of infectious complications later on. Changes in the neutrophil compartment can be used as read out of the amplitude of the immune response after trauma. The study aim was to test whether 24/7 point-of-care analysis of neutrophil marker expression by automated flow cytometry can be achieved after trauma.
designA prospective cohort study was performed. Polytrauma patients who developed infectious complications were compared with polytrauma patients who did not develop infectious complications.
settingThe study was performed in a level 1 trauma center. PATIENTS: All trauma patients presented in the trauma bay were included.
interventionsAn extra blood tube was drawn from all patients. Thereafter, a member of the trauma team placed the blood tube in the fully automated flow cytometer, which was located in the corner of the trauma room. Next, a modified and tailored protocol for this study was automatically performed. MAIN
resultsThe trauma team was able to successfully start the point-of-care automated flow cytometry analysis in 156 of 164 patients, resulting in a 95% success rate. Polytrauma patients who developed infectious complications had a significantly higher %CD16
conclusionsThis study showed the feasibility of the implementation of a fully automated point-of-care flow cytometry system for the characterization of the cellular innate immune response in trauma patients. This study supports the concept that the assessment of CD16
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Registered trials
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