Evidence map›Paper›PMID 32766437›Full record

ArticleTransplantation direct2020

Cellular Mechanisms of Rejection of Optic and Sciatic Nerve Transplants: An Observational Study.

Merve Yonar, Mayuko Uehara, Naima Banouni, Vivek Kasinath, Xiaofei Li, Liwei Jiang, Jing Zhao, Fengfeng Bei, Su Ryon Shin, Curtis L Cetrulo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Merve YonarTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Mayuko UeharaTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Naima BanouniTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Vivek KasinathTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Xiaofei LiTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Liwei JiangTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Jing ZhaoTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Fengfeng BeiDepartment of Neurosurgery, Brigham and Women's Hospital/Harvard Medical School, Cambridge, MA.
Su Ryon ShinDivision of Engineering in Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Curtis L CetruloDepartment of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA.
Nasim AnnabiChemical and Biomolecular Engineering Department and Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA.
Reza AbdiTransplantation Research Center, Renal Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrgan transplantation is a standard therapeutic strategy for irreversible organ damage, but the utility of nerve transplantation remains generally unexplored, despite its potential benefit to a large patient population. Here, we aimed to establish a feasible preclinical mouse model for understanding the cellular mechanisms behind the rejection of peripheral and optic nerves.

methodsWe performed syngenic and allogenic transplantation of optic and sciatic nerves in mice by inserting the nerve grafts inside the kidney capsule, and we assessed the allografts for signs of rejection through 14 d following transplantation. Then, we assessed the efficacy of CTLA4 Ig, Rapamycin, and anti-CD3 antibody in suppressing immune cell infiltration of the nerve allografts.

resultsBy 3 d posttransplantation, both sciatic and optic nerves transplanted from BALB/c mice into C57BL/6J recipients contained immune cell infiltrates, which included more CD11b

conclusionsThese findings establish the feasibility of a preclinical allogenic nerve transplantation model and provide the basis for future testing of directed, high-intensity immunosuppression in these mice.

Identifiers

PMID32766437
PMCPMC7382554
OpenAlexW3048863998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.