Evidence map›Paper›PMID 32766425›Full record

ArticleTransplantation direct2020

Trends in Living Donation by Race and Ethnicity Among Children With End-stage Renal Disease in the United States, 1995-2015.

Sandra Amaral, Charles E McCulloch, Elizabeth Black, Erica Winnicki, Brian Lee, Garret R Roll, Barbara Grimes, Elaine Ku

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Review
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sandra AmaralDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Elizabeth BlackDivision of Pediatric Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, CA.
Erica WinnickiDivision of Pediatric Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, CA.
Brian LeeDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA.
Garret R RollDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA.
Barbara GrimesDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Elaine KuDivision of Pediatric Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, CA.
University of California, San Francisco · USUniversity of Pennsylvania · US

Funding

Academic Training Program in NephrologyT32DK007219 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 1986 to 2022
$7.3M
Racial disparities in access to kidney transplantationR01DK115629 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI R. Adams Dudley, KIRSTEN L. JOHANSEN · 2018 to 2026
$4.5M
Reaching Equity for Adults and CHildren in Transplant (REACH-TRANSPLANT)R01DK120886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMARAL, SANDRA, KU, ELAINE · 2019 to 2023
$3.5M
NIDDK NIH HHS R01 DK115629NIDDK NIH HHS R01 DK120886NIDDK NIH HHS T32 DK007219
6 · The paper itself

Abstract

backgroundLiving donor kidney transplants have declined among adults with end-stage renal disease (ESRD), with increases in racial/ethnic disparities over time. Secular trends in racial/ethnic disparities in living donor kidney transplantation have not been well studied in children.

methodsUsing multivariable Cox modeling, we examined changes in living donor kidney transplant rates over time and probability of receiving living donor kidney transplantation within 2 years of incident ESRD by race/ethnicity among 19 772 children in the US Renal Data System, 1995-2015. We also examined racial/ethnic concordance between donors and recipients.

resultsOverall, living donor kidney transplant rates declined by 3% annually since 1995 for all racial/ethnic groups except Asians for whom living donor kidney transplant rates remained stable; however, disparities persist. Compared with non-Hispanic white children, Hispanics were 42% less likely (adjusted hazard ratio: 0.58; 95% confidence interval: 0.49-0.67), Asians 39% less likely (0.61; 0.47-0.79), and blacks 66% less likely (0.34; 0.28-0.42) to receive living kidney donor transplantation within 2 years, even when accounting for deceased donor transplantation as a competing risk. Additionally, while 95% of non-Hispanic white children had non-Hispanic white donors, only 56% of Asian recipients had Asian donors (

conclusionsThere are ongoing declines in living donation for children with ESRD for uncertain reasons, and minority populations experience significantly reduced access to timely living donor transplant, even when accounting for changes in deceased donation and donor-recipient relationships.

Identifiers

PMID32766425
PMCPMC7339334
OpenAlexW3045184268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.