Evidence map›Paper›PMID 32766213›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Delivery of Human Stromal Vascular Fraction Cells on Nanofibrillar Scaffolds for Treatment of Peripheral Arterial Disease.

Caroline Hu, Tatiana S Zaitseva, Cynthia Alcazar, Peter Tabada, Steve Sawamura, Guang Yang, Mimi R Borrelli, Derrick C Wan, Dung H Nguyen, Michael V Paukshto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  5. Review
  6. Biomedical Applications of Collagen.Bioengineering (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Nanotechnology in interventional cardiology: A state-of-the-art review.International journal of cardiology. Heart & vasculature · 2022
    Review
  9. Micro- and nanoscale biophysical cues for cardiovascular disease therapy.Nanomedicine : nanotechnology, biology, and medicine · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Caroline HuVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Tatiana S ZaitsevaFibralign Corporation, Inc., Union City, CA, United States.
Cynthia AlcazarVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Peter TabadaFibralign Corporation, Inc., Union City, CA, United States.
Steve SawamuraFibralign Corporation, Inc., Union City, CA, United States.
Guang YangThe Stanford Cardiovascular Institute, Stanford University, Palo Alto, CA, United States.
Mimi R BorrelliDivision of Plastic and Reconstructive Surgery, Stanford University, Palo Alto, CA, United States.
Derrick C WanDivision of Plastic and Reconstructive Surgery, Stanford University, Palo Alto, CA, United States.
Dung H NguyenDivision of Plastic and Reconstructive Surgery, Stanford University, Palo Alto, CA, United States.
Michael V PaukshtoFibralign Corporation, Inc., Union City, CA, United States.
Ngan F HuangVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Fibralign (United States) · USStanford University · USCardiovascular Institute of the South · USVA Palo Alto Health Care System · US

Funding

Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia: Sex Differences Administrative SupplementR01HL127113 · NHLBI · STANFORD UNIVERSITY · PI HUANG, NGAN F. · 2016 to 2020
$2.5M
Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cellsR01HL142718 · NHLBI · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2018 to 2021
$1.6M
Engineering Vascularized Skeletal Muscle for Treatment of Volumetric Muscle LossI01BX004259 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Ngan F. Huang · 2019 to 2026
–
BLRD VA I01 BX002310BLRD VA I01 BX004259NHLBI NIH HHS R01 HL127113NHLBI NIH HHS R01 HL142718
6 · The paper itself

Abstract

Cell therapy for treatment of peripheral arterial disease (PAD) is a promising approach but is limited by poor cell survival when cells are delivered using saline. The objective of this study was to examine the feasibility of aligned nanofibrillar scaffolds as a vehicle for the delivery of human stromal vascular fraction (SVF), and then to assess the efficacy of the cell-seeded scaffolds in a murine model of PAD. Flow cytometric analysis was performed to characterize the phenotype of SVF cells from freshly isolated lipoaspirate, as well as after attachment onto aligned nanofibrillar scaffolds. Flow cytometry results demonstrated that the SVF consisted of 33.1 ± 9.6% CD45

Indexed as

aligned scaffoldangiogenesisanisotropyhindlimb ischemiaperipheral arterial diseasestem cell therapy

Identifiers

PMID32766213
PMCPMC7380169
OpenAlexW3043456238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.