Evidence map›Paper›PMID 32765862›Full record

ArticleBiomedical reports2020

Effects of ketamine on neurogenesis, extracellular matrix homeostasis and proliferation in hypoxia-exposed HT22 murine hippocampal neurons.

Thomas Pichl, Titus Keller, Christoph Hünseler, Bernhard Roth, Ruth Janoschek, Sarah Appel, Eva Hucklenbruch-Rother

Open access · diamondAbstract read
In one paragraph

Article in Biomedical reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas PichlDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Titus KellerDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Christoph HünselerDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Bernhard RothDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Ruth JanoschekDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Sarah AppelDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
Eva Hucklenbruch-RotherDepartment of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital, D-50931 Cologne, Germany.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketamine is a widely used drug in pediatric anesthesia, and both neurotoxic and neuroprotective effects have been associated with its use. There are only a few studies to date which have examined the effects of ketamine on neurons under hypoxic conditions, which may lead to severe brain damage and poor neurocognitive outcomes in neonates. In the present study, the effects of ketamine on cellular pathways associated with neurogenesis, extracellular matrix homeostasis and proliferation were examined

Indexed as

cell linecell proliferationextracellular matrixhypoxiaketamineneurogenesis

Identifiers

PMID32765862
PMCPMC7403805
OpenAlexW3043812670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.