Evidence map›Paper›PMID 32765617›Full record

ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2020

The association between expression of p53 and aggressiveness of serous adenocarcinoma of the uterine cervix.

Sul Lee, Hyun Joo Lee, Kyung Un Choi, Byung Su Kwon, Dong Soo Suh, Dae Hoon Jeong, Geun Joo Kim, Tae Hwa Lee, Hyun-Jin Roh, Ki Hyung Kim

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In one paragraph

Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sul LeeDepartment of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, South Korea.
Hyun Joo LeeDepartment of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, South Korea.
Kyung Un ChoiBiomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
Byung Su KwonDepartment of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, South Korea.
Dong Soo SuhDepartment of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, South Korea.
Dae Hoon JeongDepartment of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Geun Joo KimDepartment of Obstetrics and Gynecology, College of Medicine, Kosin University Gospel Hospital, Kosin University, Busan, South Korea.
Tae Hwa LeeDepartment of Obstetrics and Gynecology, College of Medicine, Kosin University Gospel Hospital, Kosin University, Busan, South Korea.
Hyun-Jin RohDepartment of Obstetrics and Gynecology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Ki Hyung KimDepartment of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, South Korea.
Pusan National University Hospital · KRKosin University Gospel Hospital · KRInje University Busan Paik Hospital · KRPusan National University · KRUlsan University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerous adenocarcinoma of the uterine cervix is an extremely rare variant of cervical adenocarcinoma. This study aimed to evaluate the clinicopathological and molecular features and outcomes of serous adenocarcinoma of the uterine cervix (SACC). MATERIALS AND

methodsThis was a retrospective study conducted based on the clinical and pathological data of seven patients diagnosed with SACC after hysterectomy, who were evaluated at the gynecologic oncologic centers between 2010 and 2019.

resultsFive cases were diagnosed at Stage IB and two at Stage IV. All patients underwent radical hysterectomy with bilateral salpingo-oophorectomy and subsequently received postoperative radiotherapy or chemotherapy. One patient showed persistent disease, and two patients suffered recurrence. Immunohistochemical study showed that three (43%) of the seven patients were positive for p53, and among these three patients, two with diffuse strong p53 expression experienced an aggressive course with recurrences at pelvic lymph nodes, lung, and brain.

conclusionHigh p53 expression and advanced stage may be associated with poorer clinical outcomes in SACC, which suggest that immunohistochemistry may contribute to the prediction of prognosis.

Indexed as

Cervixclinicopathologic featuresserous adenocarcinoma

Identifiers

PMID32765617
PMCPMC7377125
OpenAlexW3048954341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.