ArticleFrontiers in genetics2020
Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike Glycoprotein.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children.Scientific reports · 2024Article
- Beta-spike-containing boosters induce robust and functional antibody responses to SARS-CoV-2 in macaques primed with distinct vaccines.Cell reports · 2023Article
- Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design.iScience · 2023Article
- Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera.Scientific reports · 2022Article
- Study of protease-mediated processes initiating viral infection and cell-cell viral spreading of SARS-CoV-2.Journal of molecular modeling · 2022Article
- Article
- Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic.Proteins · 2022Article
- Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.Vaccine · 2022Article
- Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Whole-genome Sequencing of SARS-CoV-2: Using Phylogeny and Structural Modeling to Contextualize Local Viral Evolution.Military medicine · 2022Article
- Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells.Journal of traditional and complementary medicine · 2022Article
- Host factors: Implications in immunopathogenesis of COVID-19.Pathology, research and practice · 2021Review
- Review
- Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.Archives of virology · 2021Article
- Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies.Scientific reports · 2021Article
- Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models.NPJ vaccines · 2021Article
- Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS-CoV-2 Spike Protein*.Angewandte Chemie (International ed. in English) · 2021Article
- Interacting Proteins, Polymorphisms and the Susceptibility of Animals to SARS-CoV-2.Animals : an open access journal from MDPI · 2021Review
- Article
- Structural Insights on the SARS-CoV-2 Variants of Concern Spike Glycoprotein: A Computational Study With Possible Clinical Implications.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The furin cleavage site in the spike glycoprotein of the SARS-CoV-2 coronavirus is considered important for the virus to enter the host cells. By analyzing 45828 SARS-CoV-2 genome sequences, we identified 103 strains of SARS-CoV-2 with various DNA mutations including 18 unique non-synonymous point mutations, one deletion, and six gains of premature stop codon that may affect the furin cleavage site. Our results revealed that the furin cleavage site might not be required for SARS-CoV-2 to enter human cells
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