Evidence map›Paper›PMID 32765504›Full record

ArticleFrontiers in immunology2020

Effects of IL-34 on Macrophage Immunological Profile in Response to Alzheimer's-Related Aβ

Leah R Zuroff, Tania Torbati, Nadav J Hart, Dieu-Trang Fuchs, Julia Sheyn, Altan Rentsendorj, Yosef Koronyo, Eric Y Hayden, David B Teplow, Keith L Black and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  11. Genome-wide scan of Flortaucipir PET levels findsmedRxiv : the preprint server for health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Leah R ZuroffNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Tania TorbatiNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Nadav J HartNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Dieu-Trang FuchsNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Julia SheynNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Altan RentsendorjNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Yosef KoronyoNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Eric Y HaydenDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.
David B TeplowDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.
Keith L BlackNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Maya Koronyo-HamaouiNeurosurgery Department, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · US

Funding

Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaR01AG055865 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Maya Koronyo-Hamaoui · 2018 to 2026
$4.9M
NIA NIH HHS R01 AG055865
6 · The paper itself

Abstract

Interleukin-34 (IL-34) is a recently discovered cytokine that acts as a second ligand of the colony stimulating factor 1 receptor (CSF1R) in addition to macrophage colony-stimulating factor (M-CSF). Similar to M-CSF, IL-34 also stimulates bone marrow (BM)-derived monocyte survival and differentiation into macrophages. Growing evidence suggests that peripheral BM-derived monocyte/macrophages (BMMO) play a key role in the physiological clearance of cerebral amyloid β-protein (Aβ). Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCD36 AntigensCells, CulturedHumansInterleukinsMacrophage Colony-Stimulating FactorMacrophagesMatrix Metalloproteinase 9MiceMice, Inbred C57BLPeptide FragmentsPhagocytosisProtein MultimerizationAmyloid beta-Peptidesamyloid beta-protein (1-42)CD36 AntigensIL34 protein, humanInterleukinsMacrophage Colony-Stimulating FactorMatrix Metalloproteinase 9Peptide FragmentsAlzheimer's diseaseamyloid-betaIL34macrophageMCSFmyeloid cellsphagocytosisscavenger receptors

Identifiers

PMID32765504
PMCPMC7378440
OpenAlexW3043392577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.