Evidence map›Paper›PMID 32765492›Full record

ArticleFrontiers in immunology2020

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis.

Kak-Ming Ling, Luke W Garratt, Erin E Gill, Amy H Y Lee, Patricia Agudelo-Romero, Erika N Sutanto, Thomas Iosifidis, Tim Rosenow, Stuart E Turvey, Timo Lassmann and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Antiviral defenses are diminished at birth in cystic fibrosis pig airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  2. Article
  3. Article
  4. Journal of virology · 2025
    Article
  5. CF airway epithelia display exaggerated host defense responses and prolonged cilia loss during RSV infection.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. A determination of pan-pathogen antimicrobials?Medicine in drug discovery · 2022
    Review
  11. The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Pseudomonas aeruginosa in the Cystic Fibrosis Lung.Advances in experimental medicine and biology · 2022
    Article
  14. Frontiers in cellular and infection microbiology · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kak-Ming LingPaediatrics, Medical School, Faculty of Healthy and Medical Science, The University of Western Australia, Nedlands, WA, Australia.
Luke W GarrattTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Erin E GillCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Amy H Y LeeCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Patricia Agudelo-RomeroTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Erika N SutantoTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Thomas IosifidisTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Tim RosenowTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Stuart E TurveyDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Timo LassmannTelethon Kids Institute, Centre for Health Research, The University of Western Australia, Nedlands, WA, Australia.
Robert E W HancockCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
Anthony KicicTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
Stephen M StickTelethon Kids Institute, Respiratory Research Centre, Nedlands, WA, Australia.
The University of Western Australia · AUUniversity of British Columbia · CAThe Kids Research Institute Australia · AU

Funding

CIHR FDN-154287
6 · The paper itself

Abstract

Early-life viral infections are responsible for pulmonary exacerbations that can contribute to disease progression in young children with cystic fibrosis (CF). The most common respiratory viruses detected in the CF airway are human rhinoviruses (RV), and augmented airway inflammation in CF has been attributed to dysregulated airway epithelial responses although evidence has been conflicting. Here, we exposed airway epithelial cells from children with and without CF to RV

Indexed as

RhinovirusBronchiCells, CulturedChild, PreschoolCystic FibrosisCytokinesEpithelial CellsFemaleHumansInfantMalePicornaviridae InfectionsProtein Interaction MapsRNA-SeqTranscriptomeCytokinesairway epithelial cellscystic fibrosisinnate immune responseRVtranscriptomic

Identifiers

PMID32765492
PMCPMC7378398
OpenAlexW3043537525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.