ReviewFrontiers in endocrinology2020
Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners.
Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial.Journal of translational medicine · 2023Trial
- Functional Foods and Sustainable Health (2nd Edition).Nutrients · 2026Article
- Universal ZnCdSe@ZnS QDs nanobead-based intelligent point-of-care testing platform for on-site detection of artificial sweetener in food.Food chemistry: X · 2026Article
- Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.Frontiers in endocrinology · 2026Article
- Comparative Analysis of the Nutrient Composition and Polyphenol Content of Organic and Sulphured Dried Apricots From Central Asia.International journal of food science · 2026Article
- Artificial Sweeteners and Cardiovascular Risk in Hungary: Beyond Traditional Risk Factors.Journal of clinical medicine · 2025Article
- Declining trends in sweetness of the diet in the United Kingdom: 2008/9-2018/19.Frontiers in nutrition · 2025Article
- Exploring the impact of artificial sweeteners on diabetes management and glycemic control.Frontiers in nutrition · 2025Review
- Food sweeteners: Angels or clowns for human health?Current research in food science · 2025Review
- Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal.eLife · 2024Article
- Dietary saccharin sodium supplementation improves the production performance of dairy goats without residue in milk in summer.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Global nutritional challenges of reformulated food: A review.Food science & nutrition · 2023Review
- The widespread presence of non-nutritive sweeteners challenges adherence to beverage guidance for children.Frontiers in public health · 2023Article
- Nutritional Quality of Pre-Packaged Foods in China under Various Nutrient Profile Models.Nutrients · 2022Article
- Nutritional Description of Foods with Low- and No-Calorie Sweeteners in Spain: The BADALI Project.Nutrients · 2022Article
- Obesity II: Establishing causal links between chemical exposures and obesity.Biochemical pharmacology · 2022Review
- Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes.Nutrients · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since excessive sugar consumption has been related to the development of chronic metabolic diseases prevalent in the western world, the use of sweeteners has gradually increased worldwide over the last few years. Although low- and non-calorie sweeteners may represent a valuable tool to reduce calorie intake and prevent weight gain, studies investigating the safety and efficacy of these compounds in the short- and long-term period are scarce and controversial. Therefore, future studies will need to elucidate the potential beneficial and/or detrimental effects of different types of sweeteners on metabolic health (energy balance, appetite, body weight, cardiometabolic risk factors) in healthy subjects and patients with diabetes, obesity and metabolic syndrome. In this regard, the impact of different sweeteners on central nervous system, gut hormones and gut microbiota is important, given the strong implications that changes in such systems may have for human health. The aim of this narrative review is to summarize the current evidence for the neuroendocrine and metabolic effects of sweeteners, as well as their impact on gut microbiota. Finally, we briefly discuss the advantages of the use of sweeteners in the context of very-low calorie ketogenic diets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.