ReviewFrontiers in neurology2020
Hematoma Expansion in Intracerebral Hemorrhage: An Update on Prediction and Treatment.
Review in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Application of Deep Learning for Predicting Hematoma Expansion in Intracerebral Hemorrhage Using Computed Tomography Scans: A Systematic Review and Meta-Analysis of Diagnostic Accuracy.La Radiologia medica · 2025Pooled it
- Pooled it
- Pooled it
- Neutrophil-to-lymphocyte ratio, white blood cell, and C-reactive protein predicts poor outcome and increased mortality in intracerebral hemorrhage patients: a meta-analysis.Frontiers in neurology · 2023Pooled it
- A systematic review and meta-analysis on the efficacy of glibenclamide in animal models of intracerebral hemorrhage.PloS one · 2023Pooled it
- Efficacy of non-enhanced computer tomography-based radiomics for predicting hematoma expansion: A meta-analysis.Frontiers in oncology · 2022Pooled it
- A multimodal prediction model for brain hematoma expansion based on deep neural network with transformer-driven collaborative attention fusion.Medical & biological engineering & computing · 2026Article
- Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Current evidence and future directions for prophylactic anticoagulation therapy after severe spontaneous intracerebral hemorrhage: a narrative review.Journal of intensive medicine · 2026Review
- Effect on Mortality of Anticoagulant Reversal in Acute Intracranial Hemorrhage: A Systematic Review and Meta-analysis.Neurocritical care · 2026Article
- Temporal Profile of Soluble TLR4 and its Association with Intracerebral Haemorrhage Expansion.Translational stroke research · 2026Article
- A novel inflammatory score predicts hematoma expansion and 90‑day functional outcomes after spontaneous intracerebral hemorrhage.Clinics (Sao Paulo, Brazil) · 2026Article
- Remote ischaemic conditioning in patients with supratentorial intracerebral haemorrhage (RICH-2): a multicentre, randomised, sham-controlled phase 3 trial in China.EClinicalMedicine · 2026Article
- Time-Dependent Association Between Prehospital Blood Pressure and Outcomes in Acute Spontaneous Intracerebral Hemorrhage.European journal of neurology · 2026Article
- Current Management of Resistant Hypertension in Patients with Intracerebral Hemorrhage.International journal of molecular sciences · 2026Review
- Monocyte-to-high-density lipoprotein cholesterol ratio predicts hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- Lower admission reverse shock index multiplied by Glasgow coma scale score is associated with early hematoma expansion in spontaneous intracerebral hemorrhage.Frontiers in neurology · 2026Article
- Non-HDL/HDL Cholesterol Ratio as a Protective Factor for Functional Recovery Following Intracerebral Hemorrhage: A Prospective Cohort Study.International journal of general medicine · 2026Article
- Hematoma expansion in intracerebral hemorrhage: neuroimaging biomarkers, radiomics-based prediction models, and clinical translation.Frontiers in human neuroscience · 2026Review
- Comparative associations of three nutritional indices with hematoma expansion after intracerebral hemorrhage.Frontiers in nutrition · 2026Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral hemorrhage (ICH) is the most lethal type of stroke, but there is no specific treatment. After years of effort, neurologists have found that hematoma expansion (HE) is a vital predictor of poor prognosis in ICH patients, with a not uncommon incidence ranging widely from 13 to 38%. Herein, the progress of studies on HE after ICH in recent years is updated, and the topics of definition, prevalence, risk factors, prediction score models, mechanisms, treatment, and prospects of HE are covered in this review. The risk factors and prediction score models, including clinical, imaging, and laboratory characteristics, are elaborated in detail, but limited by sensitivity, specificity, and inconvenience to clinical practice. The management of HE is also discussed from bench work to bed practice. However, the upmost problem at present is that there is no treatment for HE proven to definitely improve clinical outcomes. Further studies are needed to identify more accurate predictors and effective treatment to reduce HE.
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