ArticleFrontiers in computational neuroscience2020
Top-Down Control of Inhibitory Granule Cells in the Main Olfactory Bulb Reshapes Neural Dynamics Giving Rise to a Diversity of Computations.
Article in Frontiers in computational neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Respiratory Coupled Oscillations as a Mechanism of Attention to the Olfactory Environment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Organizational Principles of the Centrifugal Projections to the Olfactory Bulb.International journal of molecular sciences · 2023Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Top-Down Control of Inhibitory Granule Cells in the Main Olfactory Bulb Reshapes Neural Dynamics Giving Rise to a Diversity of Computations.Frontiers in computational neuroscience · 2020Article
- Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Growing evidence shows that top-down projections from excitatory neurons in piriform cortex selectively synapse onto local inhibitory granule cells in the main olfactory bulb, effectively gating their own inputs by controlling inhibition. An open question in olfaction is the role this feedback plays in shaping the dynamics of local circuits, and the resultant computational benefits it provides. Using rate models of neuronal firing in a network consisting of excitatory mitral and tufted cells, inhibitory granule cells and top-down piriform cortical neurons, we found that changes in the weight of feedback to inhibitory neurons generated diverse network dynamics and complex transitions between these dynamics. Changes in the weight of top-down feedback supported a number of computations, including both pattern separation and oscillatory synchrony. Additionally, the network could generate gamma oscillations though a mechanism we termed
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Registered trials
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