ArticleClinical epidemiology2020
Fetal Programming of Semen Quality (FEPOS) Cohort - A DNBC Male-Offspring Cohort.
Article in Clinical epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Body fat percentage in relation to semen characteristics, testicular volume, and reproductive hormones: a cross-sectional study.Human reproduction (Oxford, England) · 2026Article
- Parental Educational Attainment at Birth and Biomarkers of Male Fecundity: A Study From the Danish National Birth Cohort.Andrology · 2026Article
- Vitamin D levels and biomarkers of male fecundity: A study from the Danish National Birth Cohort.Andrology · 2026Article
- Season of birth and variations in male reproductive health: A population-based cohort study.Andrology · 2026Article
- Fetal exposure to a mixture of endocrine-disrupting chemicals and biomarkers of male fecundity: A population-based cohort study.Andrology · 2026Article
- Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.Environmental research · 2025Article
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- Birth by caesarean section and semen quality in adulthood: a Danish population-based cohort study.Reproductive health · 2024Article
- Maternal pre-pregnancy BMI and reproductive health in adult sons: a study in the Danish National Birth Cohort.Human reproduction (Oxford, England) · 2024Article
- The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys: a cohort study and an instrumental variable analysis.International journal of epidemiology · 2023Article
- Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study.Nutrients · 2023Article
- Maternal vitamin D levels and male reproductive health: a population-based follow-up study.European journal of epidemiology · 2023Article
- Maternal intake of folate and folic acid during pregnancy and markers of male fecundity: A population-based cohort study.Andrology · 2023Article
- A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark.Clinical epidemiology · 2023Review
- Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons.International journal of environmental research and public health · 2022Article
- Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS.Environmental health perspectives · 2022Article
- Gamete and embryo donation for research: what might shape the willingness to donate among gamete donors and recipients?Journal of assisted reproduction and genetics · 2022Article
- Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Parental Separation and Semen Quality in Young Men: A Population-Based Cohort Study.Clinical epidemiology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men.
methodsYoung adult men at least 18 years and 9 months of age born to women in the Danish National Birth Cohort living in relative proximity to Copenhagen or Aarhus and for whom a maternal blood sample and two maternal interviews during pregnancy were available were invited to FEPOS. Recruitment began in March 2017 and ended in December 2019. The participants answered a comprehensive questionnaire and underwent a physical examination where they delivered a semen, urine, and hair sample, measured their own testicular volume, and had blood drawn.
resultsIn total 21,623 sons fulfilled eligibility criteria of whom 5697 were invited and 1058 participated making the response rate 19%. Semen characteristics did not differ between sons from the Copenhagen and Aarhus clinics. When comparing the FEPOS semen parameters to similar cohorts, the median across all semen characteristics was slightly lower for FEPOS participants, although with smaller variation.
conclusionWith its 1058 young adult men, the FEPOS cohort is the largest population-based male-offspring cohort worldwide specifically designed to investigate prenatal determinants of semen quality. Wide-ranging information on maternal health, lifestyle, socioeconomic status, occupation, and serum concentrations of potential reproductive toxicants during pregnancy combined with biological markers of fertility in their sons collected after puberty allow for in-depth investigations of the 'fetal origins of adult disease hypothesis'.
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