ReviewClinical and experimental gastroenterology2020
The Humanistic and Economic Burden of Chronic Idiopathic Constipation in the USA: A Systematic Literature Review.
Review in Clinical and experimental gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05723731 (Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation: A Randomized Controlled Trial
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Safety and Efficacy of Manual and Automated Abdominal Colonic Massage for Chronic Constipation: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2026Pooled it
- Research on the mechanism of core acupoints in electroacupuncture for functional constipation based on data mining and network acupuncture.Frontiers in medicine · 2024Pooled it
- Tai Chi's synergistic modulation on autonomic nervous activity and central autonomic networks in functional constipation patients: a randomized controlled trial.Scientific reports · 2025Trial
- Bowel health, defecation patterns and nutrient intake following adoption of a vegan diet: a randomized-controlled trial.Annals of medicine · 2024Trial
- Trial
- Constipation with bloating: a clinical approach to evaluation and management.Annals of medicine · 2026Review
- Rothia mucilaginosa alleviates constipation through gut microbiota remodeling and neuroactive pathway activation.BMC microbiology · 2026Article
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Treatment Patterns, Perceptions, Barriers, and Costs in Patients With Chronic Idiopathic Constipation in the United States.Gastro hep advances · 2026Article
- Inverse association of alcohol consumption patterns with constipation and diarrhea: a population-based cross-sectional study.BMC gastroenterology · 2025Article
- Antegrade Continence Enema vs. Botulinum Toxin in Pediatric Chronic Idiopathic Constipation: A 10-Year Retrospective Study at a Single Center.Children (Basel, Switzerland) · 2025Article
- Negative association between body roundness index and constipation: insights from NHANES.Journal of health, population, and nutrition · 2025Article
- Healthcare Utilization and Costs of Care in Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation After Initiating Oral Therapies: Real-World Analysis in the US Medicare Population.Advances in therapy · 2025Article
- Association of constipation with suicidal ideation among US adults and the partial mediating role of depression.Scientific reports · 2025Article
- Article
- Artificial intelligence as a transforming factor in motility disorders-automatic detection of motility patterns in high-resolution anorectal manometry.Scientific reports · 2025Article
- Cost-Effectiveness of Vibrant System vs. Linaclotide in Chronic Idiopathic Constipation.Advances in therapy · 2025Article
- Economic Burden of Patients With Chronic Idiopathic Constipation in the USA Before and After Prucalopride Initiation.Gastro hep advances · 2025Article
- Article
- Capsule robots for the monitoring, diagnosis, and treatment of intestinal diseases.Materials today. Bio · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic idiopathic constipation (CIC) is a functional gastrointestinal disorder with an estimated prevalence of 16% in the USA; however, the humanistic and economic burden of CIC is poorly characterized.
aimThis systematic literature review aimed to assess the humanistic and economic burden of CIC in adults in the USA.
methodsTwo systematic literature searches of English-language publications on the humanistic and economic burden of CIC in adults in the USA were conducted using electronic databases and other resources. Both searches included the terms "chronic idiopathic constipation" and "functional constipation". Specific terms used in the search on humanistic burden included "quality of life", "SF-36", "SF-12", and "PAC-QOL"; search terms for economic burden included "cost", "resource use", "absenteeism", and "productivity".
resultsOverall, 16 relevant articles were identified. Health-related quality of life (HRQoL) appeared to be reduced in patients with CIC compared with controls and the general US population. Abdominal (
conclusionThe reduced HRQoL and increased costs associated with CIC indicate unmet therapeutic need in this disorder. Further research is required to better understand the humanistic and economic burden of CIC in the USA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.