ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2020
Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Sex-specific hepatic effects of sweetened alcohol consumption and tannic acid intervention in adolescent rats.Physiological reports · 2026Article
- Changes in uric acid metabolism and associated plasma proteomics during sex hormone therapy.Journal of clinical & translational endocrinology · 2026Article
- Correlation Analysis of Body Muscle-Fat Composition Parameters and CT Severity Index with Disease Severity in Acute Pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Uric Acid to Platelet Ratio (UAPR) and Its Link to Lipid Abnormalities: Findings from a Large Cohort Study in Saudi Arabia.Journal of clinical medicine · 2025Article
- Non-linear association between visceral adipose tissue area and serum uric acid concentration in US adults: findings from NHANES 2011-2018.BMC public health · 2025Article
- Association Between TyG-BMI Index and Hyperuricemia in Adult Women.Endocrinology, diabetes & metabolism · 2025Article
- The association between the cardiometabolic index and hyperuricemia: 2011-2016 NHANES.Frontiers in endocrinology · 2025Article
- TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Exploring the S-shaped relationship between triglyceride-glucose index and serum uric acid levels in individuals with osteoporotic fracture.Frontiers in endocrinology · 2025Article
- Associations of Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Trunk Fat Mass and Visceral Fat Accumulation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years.Frontiers in endocrinology · 2024Article
- Correlation Between Abdominal Fat Distribution and Serum Uric Acid in Patients Recently Diagnosed with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Associations Between Low Serum Urate, Body Composition, and Mortality.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study.International journal of endocrinology · 2023Article
- Hyperuricemia, a Non-Independent Component of Metabolic Syndrome, Only Predicts Renal Outcome in Chronic Kidney Disease Patients without Metabolic Syndrome or Diabetes.Biomedicines · 2022Article
- Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China.Frontiers in endocrinology · 2022Article
- Association Between Triglyceride-Glucose Index and Serum Uric Acid Levels: A Biochemical Study on Anthropometry in Non-Obese Type 2 Diabetes Mellitus Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association of obesity, triglyceride-glucose and its derivatives index with risk of hyperuricemia among college students in Qingdao, China.Frontiers in endocrinology · 2022Article
- The Association Between Total Percent Fat and Serum Uric Acid in Adults.Frontiers in nutrition · 2022Article
- Perirenal Fat Volume Is Positively Associated With Serum Uric Acid Levels in Chinese Adults.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM).
methodsA total of 867 patients with T2DM were enrolled. Measurements of central fat distribution were obtained by dual energy X-ray absorptiometry. Patients were stratified into three groups according to their levels of serum uric acid (SUA). Multiple linear regression analysis was used to determine the association between SUA and central body fat distribution. Logistic regression analysis was used to estimate the risk factors for hyperuricemia (HUA). Mediation analysis was applied to assess the overall, direct, and indirect mediators of SUA levels.
resultsMultiple linear regression analysis showed that SUA levels were significantly positively correlated with waist circumference (WC), body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), Android fat mass, Gynoid fat mass, fasting c-peptide (F-CP), and area under the curve of C-peptide (P < 0.05 for all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078-5.197; P < 0.001)], WC (OR, 1.041; 95% CI, 1.011-1.072; P < 0.001), high-density lipoprotein (OR, 0.274; 95% CI, 0.104-0.727; P < 0.001), and estimated glomerular filtration rate (OR, 0.966; 95% CI, 0.959-0.973; P < 0.001) were found to be independent risk factors for T2DM patients with HUA. After mediation analysis, BMI and central obesity were found to have different partial effects on the association between SUA and F-CP (P < 0.001).
conclusionIn patients with T2DM, HUA was positively correlated with F-CP and central body fat distribution, especially VAT. These results suggest that central obesity may play a role in the positive correlation between HUA and insulin resistance (IR).
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