Evidence map›Paper›PMID 32765010›Full record

ArticleInfection and drug resistance2020

Evaluation of the Anti-Leishmanial Effect of Recombinant

Fatemeh Namdar, Hossein Khanahmad, Zahra Ghayour, Farzaneh Mirzaei, Azam Namdar, Maryam Aghaei, Shahrokh Izadi, Faham Khamesipour, Seyed Hossein Hejazi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. A novel inhibitory strategy ofFuture microbiology · 2025
    Article
  2. Anti-tumor Effects of Recombinant Clostridium α-Toxin on Breast Cancer: AnInternational journal of molecular and cellular medicine · 2024
    Article
  3. Genetic diversity ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Fatemeh NamdarDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0003-4172-4315
Hossein KhanahmadDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Zahra GhayourDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Farzaneh MirzaeiDepartment of Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Azam NamdarDepartment of Community Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Maryam AghaeiSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Shahrokh IzadiDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Faham KhamesipourCellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Seyed Hossein HejaziDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IRFasa University of Medical Sciences · IRSabzevar University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeishmaniasis is an infectious disease common in tropical and subtropical regions caused by the genus MATERIALS AND

methodsProduction, expression, and purification of recombinant α-toxin were evaluated by SDS-PAGE and Western blotting techniques. The antileishmanial activities of the purified α-toxin plus and without glucantime were examined in vitro and in vivo.

resultsThe results indicated successful expression of α-toxin as a 48 kDa band on SDS-PAGE and Western blot methods. Also, evaluation of α-toxin IC

conclusionThe results showed recombinant α-toxin has synergistic effects with glucantime in destroying

Indexed as

Clostridium septicumin vitroin vivoLeishmaniaparasitic diseasesα-toxin

Identifiers

PMID32765010
PMCPMC7369417
OpenAlexW3042468908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.