Evidence map›Paper›PMID 32764939›Full record

ArticleInternational journal of nanomedicine2020

Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.

Carol M Cleetus, Fabian Alvarez Primo, Gisel Fregoso, Nivedita Lalitha Raveendran, Juan C Noveron, Charles T Spencer, Chinatalapalle V Ramana, Binata Joddar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  12. [Research advances in three-dimensional bioprinted wound dressings].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carol M CleetusDepartment of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.
Fabian Alvarez PrimoDepartment of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-6917-723X
Gisel FregosoDepartment of Electrical and Computer Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.
Nivedita Lalitha RaveendranDepartment of Mechanical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-4373-3912
Juan C NoveronDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.
Charles T SpencerDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0001-8121-8463
Chinatalapalle V RamanaDepartment of Mechanical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.
Binata JoddarDepartment of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-9157-3140

Funding

Phase II of BUILDing SCHOLARSUL1GM118970 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$17.9M
Phase II of BUILDing SCHOLARS - Student Training CoreTL4GM118971 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$9.9M
Phase II of BUILDing SCHOLARS - Research Enrichment CoreRL5GM118969 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$7.4M
Bioprinting of human iPSCs to facilitate their differentiation, recruitment and strategic assembly to form engineered cardiac patchesSC2HL134642 · NHLBI · UNIVERSITY OF TEXAS EL PASO · PI JODDAR, BINATA · 2016 to 2018
$438k
NHLBI NIH HHS SC2 HL134642NIGMS NIH HHS RL5 GM118969NIGMS NIH HHS TL4 GM118971NIGMS NIH HHS UL1 GM118970
6 · The paper itself

Abstract

introductionIn this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing. We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.

methodsThe antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis. Titanium dioxide (TiO

results3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples. For all samples, the addition of ZnO or TiO DISCUSSION: The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing. This scaffold can provide a cost-effective and durable antibacterial treatment option.

Indexed as

AlginatesCell SurvivalFibroblastsHydrogelsNanoparticlesWound HealingZinc OxideAlginatesHydrogelsZinc Oxide3D printingalginate hydrogels/scaffoldsantibacterialchronic wound healinghydroxyl radicalszinc oxide nanoparticles

Identifiers

PMID32764939
PMCPMC7369368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.